Evidence map›Paper›PMID 37332606›Full record

ArticleiScience2023

Targeting the PRC2-dependent epigenetic program alleviates urinary tract infections.

Chunming Guo, Mingyi Zhao, Xinbing Sui, Zarine Balsara, Songhui Zhai, Michael Ahdoot, Yingsheng Zhang, Christa M Lam, Ping Zhu, Xue Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Chunming GuoSamuel Oschin Comprehensive Cancer Institute, Department of Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Davis 3089, Los Angeles, CA 90048, USA.
Mingyi ZhaoDepartments of Urology and Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Xinbing SuiDepartments of Urology and Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Zarine BalsaraDepartments of Urology and Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Songhui ZhaiDepartments of Urology and Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Michael AhdootDepartment of Surgery, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Davis 3089, Los Angeles, CA 90048, USA.
Yingsheng ZhangSamuel Oschin Comprehensive Cancer Institute, Department of Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Davis 3089, Los Angeles, CA 90048, USA.
Christa M LamSamuel Oschin Comprehensive Cancer Institute, Department of Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Davis 3089, Los Angeles, CA 90048, USA.
Ping ZhuGuangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Pathogenesis, Guangzhou Key Laboratory of Cardiac Pathogenesis and Prevention, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, Guangdong 510100, China.
Xue LiSamuel Oschin Comprehensive Cancer Institute, Department of Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Davis 3089, Los Angeles, CA 90048, USA.
Cedars-Sinai Medical Center · USHarvard University · USGuangdong Provincial People's Hospital · CNSouthern Medical University · CN

Funding

Transcriptional Regulation of Urothelial Differentiation During Homeostasis and Repair in Response to Urinary Tract InfectionU54DK104309 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JONATHAN M. BARASCH, ALI G GHARAVI · 2014 to 2026
$17.7M
Sexual Dimorphism in Bladder CancerR01CA267108 · NCI · CEDARS-SINAI MEDICAL CENTER · PI Xue Sean Li · 2022 to 2026
$2.9M
The single and same cell 3D atlas of epigenome and transcriptome of the lower urinary tractU01DK131377 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI LI, XUE SEAN · 2021 to 2025
$2.3M
The Six-Family Genes in Cardiovascular Development And DiseaseR01HL136921 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI LI, XUE SEAN · 2017 to 2020
$2.3M
Molecular Basis of Sexually Dimorphic Development of the Genital TubercleR01DK110477 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI LI, XUE SEAN · 2017 to 2021
$1.9M
The Impact of Gut Microbiota on the Sex Difference in Bladder CancerR21CA249701 · NCI · CEDARS-SINAI MEDICAL CENTER · PI LI, XUE SEAN · 2021 to 2022
$425k
NCI NIH HHS R01 CA267108NCI NIH HHS R21 CA249701NHLBI NIH HHS R01 HL136921NIDDK NIH HHS R01 DK110477NIDDK NIH HHS U01 DK131377NIDDK NIH HHS U54 DK104309
6 · The paper itself

Abstract

Urinary tract infection (UTI) is a pervasive health problem worldwide. Patients with a history of UTIs suffer increased risk of recurrent infections, a major risk of antibiotic resistance. Here, we show that bladder infections induce expression of

Indexed as

EpigeneticsHealth sciencesImmunologyMolecular mechanism of gene regulation

Identifiers

PMID37332606
PMCPMC10272480
OpenAlexW4377115951

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.