ArticleiScience2023
The temporal pattern of synaptic activation determines the longevity of structural plasticity at dendritic spines.
Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Altered Structural Plasticity Mediated by mGlu and NMDA Receptors and Impaired Cognition in a Genetic ASD Model (Shank3The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A synapse-specific refractory period for plasticity at individual dendritic spines.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A synapse-specific refractory period for plasticity at individual dendritic spines.bioRxiv : the preprint server for biology · 2024Article
- Homosynaptic plasticity induction causes heterosynaptic changes at the unstimulated neighbors in an induction pattern and location-specific manner.Frontiers in cellular neuroscience · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Learning is thought to involve physiological and structural changes at individual synapses. Synaptic plasticity has predominantly been studied using regular stimulation patterns, but neuronal activity in the brain normally follows a Poisson distribution. We used two-photon imaging and glutamate uncaging to investigate the structural plasticity of single dendritic spines using naturalistic activation patterns sampled from a Poisson distribution. We showed that naturalistic activation patterns elicit structural plasticity that is both NMDAR and protein synthesis-dependent. Furthermore, we uncovered that the longevity of structural plasticity is dependent on the temporal structure of the naturalistic pattern. Finally, we found that during the delivery of the naturalistic activity, spines underwent rapid structural growth that predicted the longevity of plasticity. This was not observed with regularly spaced activity. These data reveal that different temporal organizations of the same number of synaptic stimulations can produce rather distinct short and long-lasting structural plasticity.
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