Evidence map›Paper›PMID 37332567›Full record

ArticleArXiv2023

Drugst.One - A plug-and-play solution for online systems medicine and network-based drug repurposing.

Andreas Maier, Michael Hartung, Mark Abovsky, Klaudia Adamowicz, Gary D Bader, Sylvie Baier, David B Blumenthal, Jing Chen, Maria L Elkjaer, Carlos Garcia-Hernandez and 29 more

Abstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

39 authors.

Andreas MaierInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.
Michael HartungInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.
Mark AbovskyDivision of Orthopaedic Surgery, Schroeder Arthritis Institute, and Data Science Discovery Centre, Osteoarthritis Research Program, Krembil Research Institute, UHN, Toronto, Canada.
Klaudia AdamowiczInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.
Gary D BaderDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Sylvie BaierChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany.
David B BlumenthalDepartment Artificial Intelligence in Biomedical Engineering (AIBE), Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany.
Jing ChenDepartment of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Maria L ElkjaerDepartment of Neurology, Odense University Hospital, Odense, Denmark.
Carlos Garcia-HernandezBarcelona Supercomputing Center (BSC), 08034 Barcelona, Spain.
Mohamed HelmyDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Markus HoffmannChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany.
Igor JurisicaDivision of Orthopaedic Surgery, Schroeder Arthritis Institute, and Data Science Discovery Centre, Osteoarthritis Research Program, Krembil Research Institute, UHN, Toronto, Canada.
Max KotlyarDivision of Orthopaedic Surgery, Schroeder Arthritis Institute, and Data Science Discovery Centre, Osteoarthritis Research Program, Krembil Research Institute, UHN, Toronto, Canada.
Olga LazarevaDivision of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Hagai LeviBlavatnik School of Computer Science, Tel-Aviv University, Tel-Aviv, Israel.
Markus ListChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany.
Sebastian LobentanzerHeidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany.
Joseph LoscalzoDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Noel Malod-DogninBarcelona Supercomputing Center (BSC), 08034 Barcelona, Spain.
Quirin ManzChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany.
Julian MatschinskeInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.
Miles MeeDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Mhaned OubounytInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.
Alexander R PicoInstitute of Data Science and Biotechnology, Gladstone Institutes, 1650 Owens Street, San Francisco, 94158, California, USA.
Rudolf T PillichDepartment of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Julian M PoschenriederInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.
Dexter PrattDepartment of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Nataša PržuljBarcelona Supercomputing Center (BSC), 08034 Barcelona, Spain.
Sepideh SadeghInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.
Julio Saez-RodriguezHeidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany.
Suryadipto SarkarDepartment Artificial Intelligence in Biomedical Engineering (AIBE), Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany.
Gideon ShakedBlavatnik School of Computer Science, Tel-Aviv University, Tel-Aviv, Israel.
Ron ShamirBlavatnik School of Computer Science, Tel-Aviv University, Tel-Aviv, Israel.
Nico TrummerChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany.
Ugur TurhanInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.
Ruisheng WangDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Olga ZolotarevaInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.
Jan BaumbachInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent decades, the development of new drugs has become increasingly expensive and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and network medicine tools have emerged to identify potential drug repurposing candidates. However, these tools often require complex installation and lack intuitive visual network mining capabilities. To tackle these challenges, we introduce Drugst.One, a platform that assists specialized computational medicine tools in becoming user-friendly, web-based utilities for drug repurposing. With just three lines of code, Drugst.One turns any systems biology software into an interactive web tool for modeling and analyzing complex protein-drug-disease networks. Demonstrating its broad adaptability, Drugst.One has been successfully integrated with 21 computational systems medicine tools. Available at https://drugst.one, Drugst.One has significant potential for streamlining the drug discovery process, allowing researchers to focus on essential aspects of pharmaceutical treatment research.

Indexed as

Biomedical data analysisBiomedical network explorationData visualizationDrug repurposingInteractive network enrichmentNetwork integrationSystems medicine

Identifiers

PMID37332567
PMCPMC10274948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.