Evidence map›Paper›PMID 37332555›Full record

ArticleInternational journal of ophthalmology2023

Assessment of the effects of intrastromal injection of adipose-derived stem cells in keratoconus patients.

Shahrokh Ramin, Ali Abbasi, Masoumeh Ahadi, Lina Moallemi Rad, Farzad Kobarfad

Abstract read
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In one paragraph

Article in International journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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  4. Brittle Cornea Syndrome: Molecular Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shahrokh RaminDepartment of Optometry, School of Rehabilitation Sciences, Incubation Center for Pharmaceutical Technology (ICPT), Shahid Beheshti University of Medical Sciences, Cell Therapy Department, Red Crescent Pharmaceutical and Clinical Complex, Tehran 1616913111, Iran.
Ali AbbasiDepartment of Optometry, School of Rehabilitation Sciences, Incubation Center for Pharmaceutical Technology (ICPT), Shahid Beheshti University of Medical Sciences, Cell Therapy Department, Red Crescent Pharmaceutical and Clinical Complex, Tehran 1616913111, Iran.
Masoumeh AhadiStudent Research Committee and Department of Optometry, School of Rehabilitation Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1616913111, Iran.
Lina Moallemi RadDepartment of Molecular and Cell Biology; Faculty of Basic Sciences, University of Mazandaran, Babolsar 4561745735, Iran.
Farzad KobarfadDepartment of Medicinal Chemistry, Shahid Beheshti School of Pharmacy, Tehran 4516745735, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the efficacy and safety of intrastromal transplantation of adipose-derived stem cells (ASCs) in keratoconus patients.

methodsThis study was conducted on 8 eyes of 8 patients with moderate to severe keratoconus. In the patients, ophthalmic assessments including visual acuity, refraction, slit lamp examination, fundoscopy, corneal topography, and confocal microscopy were performed. Autologous stem cells were used. The isolated stem cells were injected into the corneal stroma by using femtosecond laser. Surgical procedure was similar to intracorneal ring implantation. All patients were re-assessed 1, 3, and 6mo after surgery.

resultsThe baseline mean visual acuity was 0.48±0.18 and improved to 0.66±0.17 after surgery and final acuity increased by 1.85±0.80 lines (

conclusionIntrastromal transplantation of ASCs has positive effects on vision and refractive parameters in most patients with keratoconus. After six months, visual acuity improved moderately, corneal parameters reduced slightly, and stromal keratocytes density increased. This modality is safe, and patients do not have any complications.

Indexed as

adipose-derived stem cellscellular therapykeratoconusstromal keratocyte

Identifiers

PMID37332555
PMCPMC10250957

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.