ArticleTemperature (Austin, Tex.)2023
Sleep disruption induces activation of inflammation and heightens risk for infectious disease: Role of impairments in thermoregulation and elevated ambient temperature.
Article in Temperature (Austin, Tex.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
- Effects of almond consumption on sleep quality in adults: a randomized controlled trial.Frontiers in nutrition · 2026Trial
- Heat-TreatedNutrients · 2025Trial
- Sleep disturbances after an ultra-trail endurance race: a field study.Sleep medicine: X · 2026Article
- Assessment of Sleep, Cognitive Performance, and Circulating Cytokines in Adults with Chronic Rhinosinusitis.Diagnostics (Basel, Switzerland) · 2026Article
- Mechanisms of Heat-Induced Sleep Disruption in Aging: A Narrative Review.Clocks & sleep · 2026Review
- Chronic Sleep Disturbance Enhances Inflammation and Collagen Production in Neural- and Myofascial Tissues in Uninjured Rats.International journal of molecular sciences · 2026Article
- HSV-1 reactivation as an emergent property of neuronal stress: implications for traumatic brain injury.Journal of neuroinflammation · 2026Review
- The effect of enhanced external counterpulsation on sleep quality and quality of life in patients with chronic insomnia: study protocol for a randomized controlled trial.BMC psychiatry · 2026Article
- Exploring the relationship between sleep patterns and cardio-renal-metabolic multimorbidity in Chinese and European populations.Journal of health, population, and nutrition · 2026Article
- Shift work and hormonal-circadian disruption raise urinary incontinence: a narrative review.Gynecology and pelvic medicine · 2026Review
- Circadian-immune crosstalk in insomnia disorder: mechanisms and therapeutic implications.Frontiers in neuroscience · 2026Review
- Chronic insomnia is associated with inflammatory, carotid atherosclerotic, MRI-based brain atrophy-related, and cognitive alterations: the potential role of IL-6.Frontiers in medicine · 2026Article
- Inflammatory Cytokines as a Shared Pathophysiological Pathway in Depression and Chronic Insomnia: A Narrative Review of Mechanisms and Clinical Implications.Neuropsychiatric disease and treatment · 2026Review
- Article
- Review
- The Effect of Tart Cherry on Sleep Quality and Sleep Disorders: A Systematic Review.Food science & nutrition · 2025Review
- Burden of heat stress on residual work capacity among farmers living with chronic HIV in Siaya county, Kenya: a longitudinal observational study protocol.BMC public health · 2025Observational
- Association between dietary insulin index and risk of depression, anxiety, and sleep disturbance in a group of Iranian physically active adults.BMC psychology · 2025Article
- Molecular Effects of Cornelian Cherry Fruit (Current issues in molecular biology · 2025Article
- Insomnia Associated With Increased Risk of Atopic Dermatitis: A Two-Sample Mendelian Randomization Study.Brain and behavior · 2025Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Thermoregulation and sleep are tightly coordinated, with evidence that impairments in thermoregulation as well as increases in ambient temperature increase the risk of sleep disturbance. As a period of rest and low demand for metabolic resources, sleep functions to support host responses to prior immunological challenges. In addition by priming the innate immune response, sleep prepares the body for injury or infection which might occur the following day. However when sleep is disrupted, this phasic organization between nocturnal sleep and the immune system becomes misaligned, cellular and genomic markers of inflammation are activated, and increases of proinflammatory cytokines shift from the nighttime to the day. Moreover, when sleep disturbance is perpetuated due to thermal factors such as elevated ambient temperature, the beneficial crosstalk between sleep and immune system becomes further imbalanced. Elevations in proinflammatory cytokines have reciprocal effects and induce sleep fragmentation with decreases in sleep efficiency, decreases in deep sleep, and increases in rapid eye movement sleep, further fomenting inflammation and inflammatory disease risk. Under these conditions, sleep disturbance has additional potent effects to decrease adaptive immune response, impair vaccine responses, and increase vulnerability to infectious disease. Behavioral interventions effectively treat insomnia and reverse systemic and cellular inflammation. Further, insomnia treatment redirects the misaligned inflammatory- and adaptive immune transcriptional profiles with the potential to mitigate risk of inflammation-related cardiovascular, neurodegenerative, and mental health diseases, as well as susceptibility to infectious disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.