Evidence map›Paper›PMID 37332088›Full record

ArticleAngewandte Chemie (International ed. in English)2023

Copper-Phosphido Catalysis: Enantioselective Addition of Phosphines to Cyclopropenes.

Brian S Daniels, Xintong Hou, Stephanie A Corio, Lindsey M Weissman, Vy M Dong, Jennifer S Hirschi, Shaozhen Nie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brian S DanielsDepartment of Chemistry, University of California, Irvine, 92697, Irvine, CA, USA.
Xintong HouDepartment of Chemistry, University of California, Irvine, 92697, Irvine, CA, USA.
Stephanie A CorioDepartment of Chemistry, Binghamton University, 13902, Binghamton, NY, USA.
Lindsey M WeissmanDepartment of Chemistry, Binghamton University, 13902, Binghamton, NY, USA.
Vy M DongDepartment of Chemistry, University of California, Irvine, 92697, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-8099-1048
Jennifer S HirschiDepartment of Chemistry, Binghamton University, 13902, Binghamton, NY, USA.
Shaozhen NieDepartment of Medicinal Chemistry, GSK, 1250 S. Collegeville Rd, 19426, Collegeville, PA, USA.

Funding

Innovative Tools for Chemical Synthesis: Metal-Hydride Catalysis, Medicinal Motifs, and Molecular ProbesR35GM127071 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Vy M Dong · 2018 to 2026
$4.9M
Mechanistic Investigation into Modern Catalytic ReactionsR35GM147183 · NIGMS · STATE UNIVERSITY OF NY,BINGHAMTON · PI Jennifer Hirschi · 2022 to 2026
$1.7M
NIGMS NIH HHS R35 GM127071NIGMS NIH HHS R35 GM147183NIGMS NIH HHS R35GM147183
6 · The paper itself

Abstract

We describe a copper catalyst that promotes the addition of phosphines to cyclopropenes at ambient temperature. A range of cyclopropylphosphines bearing different steric and electronic properties can now be accessed in high yields and enantioselectivities. Enrichment of phosphorus stereocenters is also demonstrated via a Dynamic Kinetic Asymmetric Transformation (DyKAT) process. A combined experimental and theoretical mechanistic study supports an elementary step featuring insertion of a Cu

Indexed as

Asymmetric CatalysisCopper-PhosphidoCyclopropenesHydrophosphination

Identifiers

PMID37332088
PMCPMC11365472

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.