Evidence map›Paper›PMID 37331812›Full record

ArticleJournal of atherosclerosis and thrombosis2023

Pathology of Critical Limb Ischemia; Comparison of Plaque Characteristics Between Anterior and Posterior Tibial Arteries.

Yutaka Koyama, Suguru Migita, Sayaka Shimodai-Yamada, Mayumi Suzuki, Kenta Uto, Yasuo Okumura, Norihiko Ohura, Hiroyuki Hao

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Photoacoustic Fingerprinting for Robust Molecular Imaging.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yutaka KoyamaDivision of Human Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine.
Suguru MigitaDivision of Human Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine.
Sayaka Shimodai-YamadaDivision of Human Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine.
Mayumi SuzukiDivision of Human Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine.
Kenta UtoDivision of Human Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine.
Yasuo OkumuraDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Norihiko OhuraDepartment of Plastic and Reconstructive Surgery, Kyorin University School of Medicine.
Hiroyuki HaoDivision of Human Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine.
Nihon University · JPKyorin University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThough the number of patients with peripheral arterial disease (PAD) and critical limb ischemia (CLI) is increasing, few histopathological studies of PAD, particularly that involving below-the-knee arteries, has been reported. We analyzed the pathology of anterior tibial artery (ATA) and posterior tibial artery (PTA) specimens obtained from patients who underwent lower extremity amputation due to CLIMethods: Dissected ATAs and PTAs were subjected to ex-vivo soft X-ray radiography, followed by pathological examination using 860 histological sections. This protocol was approved by the Ethics Review Board of Nihon University Itabashi Hospital (RK-190910-01) and Kyorin University Hospital (R02-179).

resultsThe calcified area distribution was significantly larger in PTAs than in ATAs on soft X-ray radiographic images (ATAs, 48.3% ±19.2 versus PTAs, 61.6% ±23.9; p＜0.001). Eccentric plaque with necrotic core and macrophage infiltration were more prominent in ATAs than in PTAs (eccentric plaque: ATAs, 63.7% versus PTAs, 49.1%; p＜0.0001, macrophage: ATAs, 0.29% [0.095 - 1.1%] versus PTAs, 0.12% [0.029 - 0.36%]; p＜0.001), histopathologically. Thromboembolic lesions were more frequently identified in PTAs than in ATAs (ATAs, 11.1% versus PTAs 15.8%; p＜0.05). Moreover, post-balloon injury pathology differed between ATAs and PTAs.

conclusionsHistological features differed strikingly between ATAs and PTAs obtained from CLI patients. Clarifying the pathological features of CLI would contribute to establishing therapeutic strategies for PAD, particularly disease involving below-the knee-arteries.

Indexed as

Peripheral Arterial DiseaseTibial ArteriesChronic Limb-Threatening IschemiaCritical IllnessHumansIschemiaLimb SalvageLower ExtremityRisk FactorsTreatment OutcomeCalcificationCritical limb ischemiaPathologyPeripheral artery diseaseThromboembolism

Identifiers

PMID37331812
PMCPMC10703562
OpenAlexW4380874213

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.