Evidence map›Paper›PMID 37331779›Full record

ReviewSeminars in radiation oncology2023

Machine Learning & Molecular Radiation Tumor Biomarkers.

Nicholas R Rydzewski, Kyle T Helzer, Matthew Bootsma, Yue Shi, Hamza Bakhtiar, Martin Sjöström, Shuang G Zhao

Abstract readReview
In one paragraph

Review in Seminars in radiation oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Monte Carlo methods to assess biological response to radiation in peripheral organs and in critical organs near the target.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicholas R RydzewskiRadiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; Department of Human Oncology, University of Wisconsin, Madison, WI.
Kyle T HelzerDepartment of Human Oncology, University of Wisconsin, Madison, WI.
Matthew BootsmaDepartment of Human Oncology, University of Wisconsin, Madison, WI.
Yue ShiDepartment of Human Oncology, University of Wisconsin, Madison, WI.
Hamza BakhtiarDepartment of Human Oncology, University of Wisconsin, Madison, WI.
Martin SjöströmDepartment of Radiation Oncology, University of California San Francisco, San Francisco, CA.
Shuang G ZhaoDepartment of Human Oncology, University of Wisconsin, Madison, WI; Carbone Cancer Center, University of Wisconsin, Madison, WI; William S. Middleton Memorial Veterans Hospital, Madison, WI. Electronic address: shgzhao@humonc.wisc.edu.

Funding

DYNAMIC MOLECULAR EVOLUTION OF TREATMENT RESISTANT CANCERDP2CA271832 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI ZHAO, SHUANG · 2021 to 2024
$2.3M
Validation of predictive liquid biomarkers for patients with metastatic prostate cancerUH2CA260389 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI ARMSTRONG, ANDREW J, HALABI, SUSAN · 2021 to 2022
$352k
NCI NIH HHS DP2 CA271832NCI NIH HHS UH2 CA260389
6 · The paper itself

Abstract

Developing radiation tumor biomarkers that can guide personalized radiotherapy clinical decision making is a critical goal in the effort towards precision cancer medicine. High-throughput molecular assays paired with modern computational techniques have the potential to identify individual tumor-specific signatures and create tools that can help understand heterogenous patient outcomes in response to radiotherapy, allowing clinicians to fully benefit from the technological advances in molecular profiling and computational biology including machine learning. However, the increasingly complex nature of the data generated from high-throughput and "omics" assays require careful selection of analytical strategies. Furthermore, the power of modern machine learning techniques to detect subtle data patterns comes with special considerations to ensure that the results are generalizable. Herein, we review the computational framework of tumor biomarker development and describe commonly used machine learning approaches and how they are applied for radiation biomarker development using molecular data, as well as challenges and emerging research trends.

Indexed as

Biomarkers, TumorNeoplasmsBiomarkersClinical Decision-MakingHumansMachine LearningPrecision MedicineBiomarkersBiomarkers, Tumor

Identifiers

PMID37331779
PMCPMC10287033

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.