ArticleImmunology1986
Stage-specific secreted antigens of the parasitic larval stages of the nematode Ascaris.
Article in Immunology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Innate Immune Response to Helminth Infections.Advances in experimental medicine and biology · 2025Review
- Excretory/Secretory Proteome of Females and Males of the HookwormPathogens (Basel, Switzerland) · 2023Article
- Article
- The liver proteome in a mouse model for Ascaris suum resistance and susceptibility: evidence for an altered innate immune response.Parasites & vectors · 2019Article
- Identification of a host collagen inducing factor from the excretory secretory proteins of Trichinella spiralis.PLoS neglected tropical diseases · 2018Article
- Identification and characterization of the major pseudocoelomic proteins of the giant kidney worm, Dioctophyme renale.Parasites & vectors · 2017Article
- Rendering the Intractable More Tractable: Tools from Caenorhabditis elegans Ripe for Import into Parasitic Nematodes.Genetics · 2015Review
- Cloning and characterization of a novel sigma-like glutathione S-transferase from the giant panda parasitic nematode, Baylisascaris schroederi.Parasites & vectors · 2015Article
- Immunoblot for the detection of Ascaris suum-specific antibodies in patients with visceral larva migrans (VLM) syndrome.Parasitology research · 2015Article
- In vitro culture of Parascaris equorum larvae and initial investigation of parasite excretory-secretory products.Parasitology research · 2014Article
- Molecular cloning and characterization of a nematode polyprotein antigen/allergen from the human and animal hookworm Ancylostoma ceylanicum.Molecular and biochemical parasitology · 2014Article
- Helminths and helminthoses in Central Europe: diseases caused by nematodes (roundworms).Wiener medizinische Wochenschrift (1946) · 2014Review
- An antigenic recombinant serine protease from Trichinella spiralis induces protective immunity in BALB/c mice.Parasitology research · 2013Article
- Proteomic analysis of the excretory-secretory products from larval stages of Ascaris suum reveals high abundance of glycosyl hydrolases.PLoS neglected tropical diseases · 2013Article
- Role of leukotrienes on protozoan and helminth infections.Mediators of inflammation · 2012Review
- Solution structure of a repeated unit of the ABA-1 nematode polyprotein allergen of Ascaris reveals a novel fold and two discrete lipid-binding sites.PLoS neglected tropical diseases · 2011Article
- Prevalence of antibodies against Ascaris suum and its association with allergic manifestations in 4-year-old children in The Netherlands: the PIAMA birth cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
- Ascaris suum-derived products suppress mucosal allergic inflammation in an interleukin-10-independent manner via interference with dendritic cell function.Infection and immunity · 2006Article
- Inactivation of single-celled Ascaris suum eggs by low-pressure UV radiation.Applied and environmental microbiology · 2006Article
- The polyprotein and FAR lipid binding proteins of nematodes: shape and monomer/dimer states in ligand-free and bound forms.European biophysics journal : EBJ · 2003Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The excretory/secretory (ES) antigens of the infective (L2) and lung-stage (L3/4) larvae of Ascaris have been characterized by radio-iodination, immunoprecipitation, and SDS-PAGE. These antigens were found to be heterogeneous, ranging in apparent molecular weights from 14,000 to 410,000, were stage-specific and were the targets of considerable antibody responses mounted in infected hosts. A major contaminant of the ES of L3/4 recovered from the lungs of host animals was found to be serum albumin, which appeared to have been processed in some way by the worm or its secretions. A comparison between the humoral responses of three species of experimental animals showed that rabbits recognized all ES components, while mice and rats responded to distinct subsets of these. The mouse was distinguished by non-recognition of a major 14,000 MW antigen that was common to both L2 and L3/4 ES. The body fluid of adult Ascaris worms (ABF) was similarly characterized, and the antibody response to this was inferior to that of ES materials in discriminating between infected and non-infected animals. The major constituent of ABF was a 14,000 MW molecule homologous to that of larval ES products. The variability in host responsiveness to Ascaris antigens, revealed by the disparate responsiveness of three species of experimental animal, and the potential of ES for serodiagnosis, might prove of significance to immunological studies of ascariasis in man. Moreover, the heterogeneity of ES components questions the assertion of previous workers that the allergenic, IgE-potentiating, and protective activities of larval ES can be ascribed to one molecular species.
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3733151PMC1453479What OpenQuestion holds
Registered trials
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