Evidence map›Paper›PMID 37331181›Full record

ArticleEnvironment international2023

Prenatal exposure to polycyclic aromatic hydrocarbons and cognition in early childhood.

Bob Sun, Erin R Wallace, Yu Ni, Christine T Loftus, Adam Szpiro, Drew Day, Emily S Barrett, Ruby H N Nguyen, Kurunthachalam Kannan, Morgan Robinson and 7 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 1 country.

Bob SunDivision of Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA.
Erin R WallaceDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA. Electronic address: wallace8@uw.edu.
Yu NiDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Christine T LoftusDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Adam SzpiroDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Drew DaySeattle Children's Research Institute, Seattle, WA, USA.
Emily S BarrettDepartment of Biostatistics and Epidemiology, Environmental and Occupational Health Sciences Institute, School of Public Health, Rutgers University, Piscataway, NJ, USA.
Ruby H N NguyenDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Kurunthachalam KannanDepartment of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA.
Morgan RobinsonDepartment of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA.
Nicole R BushDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California, San Francisco, San Francisco, CA, USA; Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Sheela SathyanarayanaDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA, USA.
Alex MasonDepartment of Preventive Medicine, University of Tennessee Health Sciences Center, Memphis, TN, USA.
Shanna H SwanIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Leonardo TrasandeDepartment of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA.
Catherine J KarrDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Kaja Z LeWinnDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
University of Washington · USNew York University · USUniversity of California, San Francisco · USBoston Children's Hospital · USCenter for Infectious Disease Research · USIcahn School of Medicine at Mount Sinai · USRutgers, The State University of New Jersey · USUniversity of Minnesota · USUniversity of Tennessee Health Science Center · US

Funding

The NYU Children’s Health & Environment Study: an ECHO CohortUH3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Akhgar Ghassabian, Leonardo Trasande · 2018 to 2026
$59.5M
Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI PANOS G. GEORGOPOULOS · 1988 to 2026
$47.4M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
The NYU Children’s Health & Environment Study: an ECHO CohortUG3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRASANDE, LEONARDO · 2016 to 2024
$26.5M
TIDES III: Endocrine Disruption, Hormones, and Sex Differences in Adolescent Airway HealthR01ES025169 · NIEHS · SEATTLE CHILDREN'S HOSPITAL · PI Sheela Sathyanarayana · 2015 to 2026
$9.5M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUG3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2016 to 2017
$5.1M
The Infant Development and the Environmental Study (TIDES)R01ES016863 · NIEHS · UNIVERSITY OF ROCHESTER · PI SWAN, SHANNA H · 2009 to 2014
$4.0M
Pregnancy Folate Status & Early Childhood Respiratory & Atopic Disease OutcomesR01HL109977 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CARROLL, KECIA NICOLE · 2011 to 2015
$3.4M
Phthalate and stressful life event exposures and pregnancy outcomes: The role of oxidative stressZIAES103313 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI FERGUSON, KELLY · 2016 to 2022
$1.9M
Intramural NIH HHS ZIA ES103313NHLBI NIH HHS R01 HL109977NIEHS NIH HHS P30 ES005022NIEHS NIH HHS P30 ES007033NIEHS NIH HHS R01 ES016863NIEHS NIH HHS R01 ES025169NIH HHS UG3 OD023271NIH HHS UG3 OD023305NIH HHS UH3 OD023271NIH HHS UH3 OD023305
6 · The paper itself

Abstract

backgroundEpidemiological evidence for gestational polycyclic aromatic hydrocarbon (PAH) exposure and adverse child cognitive outcomes is mixed; little is known about critical windows of exposure.

objectiveWe investigated associations between prenatal PAH exposure and child cognition in a large, multi-site study.

methodsWe included mother-child dyads from two pooled prospective pregnancy cohorts (CANDLE and TIDES, N = 1,223) in the ECHO-PATHWAYS Consortium. Seven urinary mono-hydroxylated PAH metabolites were measured in mid-pregnancy in both cohorts as well as early and late pregnancy in TIDES. Child intelligence quotient (IQ) was assessed between ages 4-6. Associations between individual PAH metabolites and IQ were estimated with multivariable linear regression. Interaction terms were used to examine effect modification by child sex and maternal obesity. We explored associations of PAH metabolite mixtures with IQ using weighted quantile sum regression. In TIDES, we averaged PAH metabolites over three periods of pregnancy and by pregnancy period to investigate associations between PAH metabolites and IQ.

resultsIn the combined sample, PAH metabolites were not associated with IQ after full adjustment, nor did we observe associations with PAH mixtures. Tests of effect modification were null except for the association between 2-hydroxynaphthalene and IQ, which was negative in males (β SIGNIFICANCE: In this multi-cohort analysis, we observed limited evidence of adverse associations of early pregnancy PAHs with child IQ. Analyses in the pooled cohorts were null. However, results also indicated that utilizing more than one exposure measures across pregnancy could improve the ability to detect associations by identifying sensitive windows and improving the reliability of exposure measurement. More research with multiple timepoints of PAH assessment is warranted.

Indexed as

Polycyclic Aromatic HydrocarbonsPrenatal Exposure Delayed EffectsChild, PreschoolCognitionFemaleHumansMalePregnancyProspective StudiesReproducibility of ResultsPolycyclic Aromatic HydrocarbonsNeurodevelopmentPolycyclic aromatic hydrocarbonsPrenatal

Identifiers

PMID37331181
PMCPMC10519343
OpenAlexW4379230153

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.