ArticlePsychiatry research2023
Gut and oral microbiome modulate molecular and clinical markers of schizophrenia-related symptoms: A transdiagnostic, multilevel pilot study.
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In one paragraph
Article in Psychiatry research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The oro- and nasopharyngeal microbiota as a revolutionary perspective on mental disorders and related psychopathology: a systematic review and meta-analysis.Journal of translational medicine · 2025Pooled it
- Microbiome-Informed Precision Electroconvulsive Therapy: Oral-Gut-Immune Signatures and Seizure Biology as Candidate Predictors of Response-A Narrative Review.Biomedicines · 2026Review
- Article
- Gut Microbiome Dysregulation Across Schizophrenia Spectrum Disorders: Bacteria-, Fungi- and Virome-Level Alterations with Molecular and Immunological Implications.International journal of molecular sciences · 2026Review
- Impact of age of onset on the course of chronic schizophrenia: factors associated with first hospitalization in a large-scale cross-sectional study.European archives of psychiatry and clinical neuroscience · 2026Article
- Gut microbial signatures in schizophrenia: exploring archaea, fungi, and bacteria.BMC psychiatry · 2026Article
- Microbiome and metabolome integrated analysis reveals oral microbiota alterations and associated metabolic pathways in allergic rhinitis.Journal of oral microbiology · 2026Article
- A taxon-centered review of bacterial shifts in psychiatric disorders.Frontiers in psychiatry · 2026Review
- Oral-Gut Microbiota Crosstalk and Epigenetic Targets in Metabolic and Neuropsychiatric Diseases.Nutrients · 2025Review
- Exploring the Gut and Oral Microbiomes in Psychoactive Substance Use: A Scoping Review of Clinical Studies.Journal of neurochemistry · 2025Article
- Oral microbiome composition is associated with depressive symptoms during pregnancy.Brain, behavior, & immunity - health · 2025Article
- Altered oral health and microbiota in drug-free patients with schizophrenia.BMC psychiatry · 2025Observational
- The gut microbiota-immune-brain axis: Therapeutic implications.Cell reports. Medicine · 2025Review
- The relationship between sarcopenic obesity and cognitive functionality among inpatients with stable schizophrenia.PloS one · 2025Article
- Altered oral microbiome composition in mental disorders: a systematic review and meta-analysis.Journal of oral microbiology · 2025Review
- Microbiome: A Key Regulator of Body-Brain Interactions.Advances in experimental medicine and biology · 2025Review
- Gut microbiome and schizophrenia: insights from two-sample Mendelian randomization.Schizophrenia (Heidelberg, Germany) · 2024Article
- Gut microbial diversity moderates polygenic risk of schizophrenia.Frontiers in psychiatry · 2024Article
- Validity of handgrip strength for assessing cognition and psychotic symptoms in hospitalized patients with stable schizophrenia.PloS one · 2024Article
- Altered oral microbiota and immune dysfunction in Chinese elderly patients with schizophrenia: a cross-sectional study.Translational psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 2 institutions in 1 country.
Jakleen J LeeDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Medical Scientist Training Program, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Enrica PirasDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Sabrina TamburiniDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Kevin BuDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Medical Scientist Training Program, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
David S WallachDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Brooke RemsenDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Adam CantorDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Jennifer KongAcademy for the Advancement of Science and Technology, Bergen County Academies, Hackensack, NJ, United States.
Deborah GoetzDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Kevin W HoffmanMedical Scientist Training Program, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Mharisi BonnerDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Peter JoeDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Bridget R MuellerDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Jessica Robinson-PappDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Eyal LotanCenter for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States.
Oded GonenCenter for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States.
Dolores MalaspinaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: dolores.malaspina@mssm.edu.
Jose C ClementeDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: jose.clemente@mssm.edu.
Icahn School of Medicine at Mount Sinai · USAdvanced Imaging Research (United States) · US
Funding
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4MTR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Daniel K Sodickson · 2014 to 2026
$19.3MJ: NRSA Training CoreTL1TR004420 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JANICE L GABRILOVE, Robert O Wright · 2022 to 2026
$3.9MHippocampal Inflammation as a Pathophysiology for PsychosisR01MH110418 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MALASPINA, DOLORES · 2017 to 2021
$3.8MMount Sinai Institutes for Clinical and Translational SciencesTL1RR029886 · NCRR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MURPHY, BARBARA T. · 2009 to 2011
$122kNCATS NIH HHS TL1 TR004420NCATS NIH HHS UL1 TR004419NCRR NIH HHS TL1 RR029886NIBIB NIH HHS P41 EB017183NIMH NIH HHS R01 MH110418
Abstract
Although increasing evidence links microbial dysbiosis with the risk for psychiatric symptoms through the microbiome-gut-brain axis (MGBA), the specific mechanisms remain poorly characterized. In a diagnostically heterogeneous group of treated psychiatric cases and nonpsychiatric controls, we characterized the gut and oral microbiome, plasma cytokines, and hippocampal inflammatory processes via proton magnetic resonance spectroscopic imaging (
Indexed as
Gastrointestinal MicrobiomeMicrobiotaSchizophreniaBiomarkersCytokinesHumansMitoguazonePilot ProjectsBiomarkersCytokinesmethylglyoxal bis(3-aminopropylamidinohydrazone)MitoguazoneCytokinesGut microbiomeHippocampal inflammationNeuroimagingOral microbiomePeripheral inflammationPsychosisSymptom domains
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.