Trial reportMedicina oral, patologia oral y cirugia bucal2023
Evaluation of bone repair with platelet-rich fibrin following the extraction of impacted third molars - randomized clinical trial.
Trial report in Medicina oral, patologia oral y cirugia bucal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Platelet-rich fibrin after mandibular third molar extraction: a split-mouth and parallel-group stratified meta-analysis of randomized controlled trials (RCTs).Oral and maxillofacial surgery · 2026Pooled it
- Analgesic effects of platelet-rich fibrin (PRF): A systematic review.Periodontology 2000 · 2025Pooled it
- Pooled it
- Effectiveness of platelet-rich fibrin in third molar extractions: a randomized controlled split-mouth study.Clinical oral investigations · 2024Trial
- Comprehensive analysis of bone tissue in extraction sockets of third molars after leukocyte and platelet rich fibrin and photobiomodulation applications.Clinical oral investigations · 2024Trial
- Can concentrated growth factor prevent postoperative complications of impacted third molar surgery? A split-mouth randomized double-blind trial.Clinical oral investigations · 2024Trial
- Expert consensus on the management of third molar health.International journal of oral science · 2026Review
- Iodine-Based Wound Dressing Versus Antibiotic Therapy for Postoperative Symptom Relief in Third Molar Surgery.Cureus · 2026Article
- Blood concentrates for controlling postoperative complications from third molar surgeries: a scoping review.Acta cirurgica brasileira · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of the present study was to evaluate postoperative effects of platelet-rich fibrin (PRF) in wound and bone healing, pain, swelling and periodontal complications outcomes after impacted third molars extraction. MATERIAL AND
methodsA prospective, randomized, split-mouth, double-blind clinical trial was conducted. PRF was placed within sockets following tooth removal and before suturing mucoperiosteal flap while no treatment was performed on control group's sockets. Patients were evaluated considering bone volume which was obtained in the 90-day postoperative period. Other variables included trabecular thickness, trabecular distance and grey values, pain, swelling, and wound healing. A Wilcoxon test and a t-Student test were used at a 5% significance level and a Friedman test was used to multiple comparisons.
resultsForty-four surgeries were performed in the present study. The patients' mean age was 22.41 (± 2.75 years) and 72.73% were women. PRF was associated to increased trabecular thickness and bone volume means (p < 0.001). The experimental group had significantly lower pain scores at 4h, 6h, 8h, 16h, 24h, and 72h (p ˂ 0.05). Mean swelling was lower on the experimental group (p < 0.001). The PRF group showed significant higher wound healing (p ˂ 0.001).
conclusionsAlveolar filling with PRF improves wound and bone healing after extractions while also decreasing pain and swelling in the postoperative period.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.