Evidence map›Paper›PMID 37330948›Full record

ReviewPulmonary therapy2023

Gaps and Future Directions in Clinical Research on Obesity-Related Asthma.

Andi C Hudler, Isaías Raymundo Ramírez Díaz, Sunita Sharma, Fernando Holguin

Open access · goldAbstract readReview
In one paragraph

Review in Pulmonary therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Emerging cell and molecular targets for treating mucus hypersecretion in asthma.Allergology international : official journal of the Japanese Society of Allergology · 2024
    Review
  4. Weight Loss Interventions for Adults With Obesity-Related Asthma.The journal of allergy and clinical immunology. In practice · 2024
    Article
  5. Article
  6. Asthma Phenotypes in the Era of Personalized Medicine.Journal of clinical medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Andi C HudlerDivision of Pulmonary Sciences and Critical Care, University of Colorado, Aurora Colorado, USA.
Isaías Raymundo Ramírez DíazFacultad Mexicana de Medicina, Universidad La Salle, Mexico City, Mexico.
Sunita SharmaDivision of Pulmonary Sciences and Critical Care, University of Colorado, Aurora Colorado, USA.
Fernando HolguinDivision of Pulmonary Sciences and Critical Care, University of Colorado, Aurora Colorado, USA. fernando.holguin@cuanschutz.edu.
University of Colorado Anschutz Medical Campus · USUniversidad La Salle · MXUniversity of Colorado Denver · US

Funding

SANDIA: Supplementing L-citrulline to overweight late Asthma oNset phenotypes to increase airway L-arginine/ADMA ratio and Improve Asthma controlR01HL146542 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI HOLGUIN, FERNANDO, QUE, LORETTA G · 2019 to 2023
$3.6M
LIMA: Lipid anti-Inflammatory Mediators in Asthma to reduce airway hyperresponsiveness in obese asthmaticsR33HL157069 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Stacy Lynn Gelhaus, Fernando Holguin · 2023 to 2026
$3.0M
LIMA: Lipid anti-Inflammatory Mediators in Asthma to reduce airway hyperresponsiveness in obese asthmaticsR61HL157069 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI GELHAUS, STACY LYNN, HOLGUIN, FERNANDO · 2022 to 2022
$742k
NHLBI NIH HHS R01 HL146542NHLBI NIH HHS R33 HL157069NHLBI NIH HHS R61 HL157069
6 · The paper itself

Abstract

Obesity is a major comorbidity for the development and worsening of asthma. It is associated with increased disease incidence, reduced response to inhaled and systemic steroids, increased asthma exacerbations, and poor disease control. Over the past two decades, we have learned that there are clinical asthma phenotypes associated with obesity, which have unique immune, inflammatory, and metabolic disease mechanisms. The objectives of this review are to provide a brief overview of the associations and gaps between these chronic inflammatory diseases and the role that traditional therapies have on treating patients with obesity-related asthma, and to describe new clinical research of therapeutic developments targeting mechanisms that are more specific to this patient population.

Indexed as

Airway inflammationAsthmaMetabolic dysregulationObesity

Identifiers

PMID37330948
PMCPMC10447703
OpenAlexW4381112511

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.