Evidence map›Paper›PMID 37330930›Full record

ArticleEuropean geriatric medicine2023

White matter hyperintensities: a possible link between sarcopenia and cognitive impairment in patients with mild to moderate Alzheimer's disease.

Xiaofen Weng, Shanwen Liu, Meng Li, Yingchun Zhang, Jiangtao Zhu, Chunfeng Liu, Hua Hu

Abstract read
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In one paragraph

Article in European geriatric medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xiaofen Weng *Department of Neurology, The Second Affiliated Hospital of Soochow University, 1055 San Xiang Road, Suzhou, 215004, Jiangsu, China.
Shanwen Liu *Department of Neurology, The Second Affiliated Hospital of Soochow University, 1055 San Xiang Road, Suzhou, 215004, Jiangsu, China.
Meng LiDepartment of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Yingchun ZhangDepartment of Ultrasonography, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Jiangtao ZhuDepartment of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Chunfeng LiuDepartment of Neurology, The Second Affiliated Hospital of Soochow University, 1055 San Xiang Road, Suzhou, 215004, Jiangsu, China.
Hua HuDepartment of Neurology, The Second Affiliated Hospital of Soochow University, 1055 San Xiang Road, Suzhou, 215004, Jiangsu, China. sz_huhua@126.com.
Second Affiliated Hospital of Soochow University · CNSoochow University · CN

Funding

Application of Clinical Technology in Elderly Health Research Project in Jiangsu Province LD2021031Jiangsu Provincial Medical Key Discipline for the 14th Five-Year Plan ZDXK202217Research Project of Neurological Diseases in the Second Affiliated Hospital of Suzhou University, Research Center ND2023A01Suzhou Science and Technology Plan Medical and Health Care Science and Technology Innovation Applied Basic Research SKY2022161
6 · The paper itself

Abstract

purposeAlzheimer's disease (AD) has been reported to be associated with sarcopenia. White matter hyperintensities (WMH) are common in AD patients. However, the effect of WMH on sarcopenia in AD remains unclear. We hence aimed to investigate the possible association between regional WMH volumes and sarcopenic parameters in AD.

methods57 mild to moderate AD patients and 22 normal controls (NC) were enrolled. Sarcopenic parameters were assessed, including appendicular skeletal mass index (ASMI), grip strength, 5-times sit-to-stand (5-STS) time, and gait speed. The volumes of periventricular hyperintensities (PVH) and deep white matter hyperintensities (DWMH) were quantified using 3D-slicer software.

resultsAD subjects exhibited a lower ASMI, a slower gait speed, an increased 5-STS time, and larger volumes of PVH and DWMH than those in the NC group. In AD subjects, total WMH and PVH volumes were related to cognitive impairment, particularly executive function decline. Moreover, total WMH volume and PVH volume were negatively correlated with gait speed across various clinical stages of AD. Multiple linear regression analysis showed that PVH volume was independently associated with 5-STS time and gait speed, whereas DWMH volume was only independently associated with gait speed.

conclusionWMH volume was associated with cognitive decline and various sarcopenic parameters. It thereby suggested that WMH may serve as the connection between sarcopenia and cognitive dysfunction in AD. Further studies are needed to confirm these findings and to determine whether sarcopenia interventions reduce WMH volume and improve cognitive function in AD.

Indexed as

Alzheimer DiseaseCognitive DysfunctionSarcopeniaWhite MatterAgedAged, 80 and overCase-Control StudiesFemaleHumansMagnetic Resonance ImagingMaleAlzheimer’s diseaseCognitive impairmentPhysical performanceSarcopeniaWhite matter hyperintensities

Identifiers

PMID37330930
OpenAlexW4381123965

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.