Evidence map›Paper›PMID 37330565›Full record

ArticleNature communications2023

Direct laser writing of 3D electrodes on flexible substrates.

Morgan A Brown, Kara M Zappitelli, Loveprit Singh, Rachel C Yuan, Melissa Bemrose, Valerie Brogden, David J Miller, Matthew C Smear, Stuart F Cogan, Timothy J Gardner

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Three-dimensional microelectrode arrays forBiomedical engineering letters · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Flexible 3D Kirigami Probes for In Vitro and In Vivo Neural Applications.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  12. 3D printing of micro-nano devices and their applications.Microsystems & nanoengineering · 2025
    Review
  13. In vivo microelectrode arrays for neuroscience.Nature reviews. Methods primers · 2025
    Article
  14. Direct-Print 3D Electrodes for Large-Scale, High-Density, and Customizable Neural Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Morgan A Brown *Phil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.
Kara M Zappitelli *Phil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.
Loveprit SinghPhil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.
Rachel C YuanPhil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.
Melissa BemrosePhil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.ORCID 0000-0002-0965-572X
Valerie BrogdenPhil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.
David J MillerPhil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.
Matthew C SmearPhil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.ORCID 0000-0003-4689-388X
Stuart F CoganDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX, USA.
Timothy J GardnerPhil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA. timg@uoregon.edu.ORCID 0000-0002-1744-3970

Funding

the self-tuning brain: cellular and circuit mechanisms of behavioral resilienceR01NS104925 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI FAIRHALL, ADRIENNE L, GARDNER, TIMOTHY JAMES · 2017 to 2022
$5.4M
Corticostriatal contributions to motor exploration and reinforcementRF1NS118424 · NINDS · DUKE UNIVERSITY · PI GARDNER, TIMOTHY JAMES, LOIS, CARLOS · 2020 to 2020
$3.7M
Corticostriatal contributions to motor exploration and reinforcementR01NS118424 · NINDS · DUKE UNIVERSITY · PI GARDNER, TIMOTHY JAMES, LOIS, CARLOS · 2023 to 2024
$2.3M
Transparent graphene electrode arrays for simultaneous electrical and optical investigation of computations in the olfactory bulbF32MH118724 · NIMH · UNIVERSITY OF OREGON · PI BROWN, MORGAN A · 2018 to 2021
$239k
NIMH NIH HHS F32 MH118724NINDS NIH HHS R01 NS104925NINDS NIH HHS R01 NS118424NINDS NIH HHS RF1 NS118424
6 · The paper itself

Abstract

This report describes a 3D microelectrode array integrated on a thin-film flexible cable for neural recording in small animals. The fabrication process combines traditional silicon thin-film processing techniques and direct laser writing of 3D structures at micron resolution via two-photon lithography. Direct laser-writing of 3D-printed electrodes has been described before, but this report is the first to provide a method for producing high-aspect-ratio structures. One prototype, a 16-channel array with 300 µm pitch, demonstrates successful electrophysiological signal capture from bird and mouse brains. Additional devices include 90 µm pitch arrays, biomimetic mosquito needles that penetrate through the dura of birds, and porous electrodes with enhanced surface area. The rapid 3D printing and wafer-scale methods described here will enable efficient device fabrication and new studies examining the relationship between electrode geometry and electrode performance. Applications include small animal models, nerve interfaces, retinal implants, and other devices requiring compact, high-density 3D electrodes.

Indexed as

Nervous SystemWritingAnimalsElectrodesElectrodes, ImplantedMiceMicroelectrodes

Identifiers

PMID37330565
PMCPMC10276853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.