ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2023
Comorbidity and risk of infection among patients with hip fracture: a Danish population-based cohort study.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 28 citations in OpenAlex.
- Preoperative chlorhexidine mouthwash can reduce the risk of postoperative pulmonary complications in elderly patients undergoing general anesthesia with endotracheal intubation.Scientific reports · 2025Trial
- Comorbidity burden and fracture pattern as predictors of early postoperative medical complications following bipolar hemiarthroplasty for displaced femoral neck fractures: a retrospective cohort study.Archives of orthopaedic and trauma surgery · 2026Article
- Interaction between mental health conditions and hip fracture on the 30-day risk of infection among older adults: a Danish matched cohort study.European geriatric medicine · 2026Article
- Full-Body Versus Local Wipe Disinfection With Chlorhexidine Gluconate: No Difference in Surgical Site Infection After Acute Hip Fracture Surgery.International wound journal · 2026Article
- Observational
- Management and optimisation in the preoperative phase for patients with a fractured hip.EFORT open reviews · 2026Review
- Supervised Machine Learning-Based Prediction of In-Hospital Mortality Following Hip Fracture in Older Adults.Diagnostics (Basel, Switzerland) · 2026Article
- The Effect of Subcutaneous Fat Tissue Length and Area on Postoperative Wound Drainage in Patients Undergoing Hemiarthroplasty for Femoral Neck Fracture.Arthroplasty today · 2026Article
- Individual and combined effects of somatic and mental disorders on reoperation risk after hip fracture surgery: a nationwide danish cohort study of 110,625 patients.European geriatric medicine · 2026Article
- Beyond bacteremia: clinical phenotypes and determinants of mortality in hospitalized adults with community-acquired urinary tract infection.Frontiers in medicine · 2026Article
- A Simple Scoring System Based on CRP/Alb Ratio, Fasting Glucose, and Surgery Duration for Predicting Postoperative Infection in Older Adult Patients with Intertrochanteric Femoral Fracture: A Retrospective Cohort Study.Infection and drug resistance · 2026Article
- In-Hospital Mortality Among 40,253 Older Adults with Hip Fracture: Survival Outcomes and Multivariate Analysis in a Chilean Cohort.Journal of clinical medicine · 2025Article
- Temporal trends in socioeconomic inequalities and risk of infection after hip fracture surgery: a nationwide cohort study, 2010-2021.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- The Long-Term Efficacy of Cephalosporin in Elderly Hip Fracture Patients: A Comprehensive Analysis.Journal of clinical medicine · 2025Article
- Correlation of Preoperative Inflammation/Immunity Markers With Postoperative Urinary Tract Infections in Elderly Hip Fracture Patients.Orthopaedic surgery · 2025Article
- Defensive antibacterial coating in orthopaedic surgery: Current evidence and future direction.World journal of orthopedics · 2025Review
- Risk factors for surgical site infection following treatment of proximal femoral fracture: a matched-pair analysis.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025Article
- Surgical timing and clinical factor predicting in-hospital mortality in older adults with hip fractures: a neuronal network analysis.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025Observational
- Infections do not play fair: the Charlson-Age Comorbidity Index reveals sex-specific risk in laparotomy patients in an LMIC.Trauma surgery & acute care open · 2025Article
- Interaction Between Multimorbidity and Hip Fracture Surgery Leads to Excess Risk of Infection: A Danish Registry-Based Cohort Study of 92,599 Patients With Hip Fracture.Clinical epidemiology · 2025Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impact of comorbidity on infection risk among hip fracture patients is unclear. We found high incidence of infection. Comorbidity was an important risk factor for infection up to 1 year after surgery. Results indicates a need for additional investment in pre- and postoperative programs that assist patients with high comorbidity. PURPOSE: Comorbidity level and incidence of infection have increased among older patients with hip fracture. The impact of comorbidity on infection risk is unclear. We conducted a cohort study examining the absolute and relative risks of infection in relation to comorbidity level among hip fracture patients.
methodsUtilizing Danish population-based medical registries, we identified 92,600 patients aged ≥ 65 years undergoing hip fracture surgery between 2004 and 2018. Comorbidity was categorized by Charlson comorbidity index scores (CCI): none (CCI = 0), moderate (CCI = 1-2), or severe (CCI ≥ 3). Primary outcome was any hospital-treated infection. Secondary outcomes were hospital-treated pneumonia, urinary tract infection, sepsis, reoperation due to surgical-site infection (SSI), and a composite of any hospital- or community-treated infection. We calculated cumulative incidence and hazard ratios (aHRs) adjusted for age, sex, and surgery year, including 95% confidence intervals (CIs).
resultsPrevalence of moderate and severe comorbidity was 40% and 19%, respectively. Incidence of any hospital-treated infection increased with comorbidity level within 0-30 days (none 13% vs. severe 20%) and 0-365 days (none 22% vs. 37% severe). Patients with moderate and severe comorbidity, compared to no comorbidity, had aHRs of 1.3 (CI: 1.3-1.4) and 1.6 (CI: 1.5-1.7) within 0-30 days, and 1.4 (CI: 1.4-1.5) and 1.9 (CI: 1.9-2.0) within 0-365, respectively. Highest incidence was observed for any hospital- or community-treated infection (severe 72%) within 0-365 days. Highest aHR was observed for sepsis within 0-365 days (severe vs. none: 2.7 (CI: 2.4-2.9)).
conclusionComorbidity is an important risk factor for infection up to 1 year after hip fracture surgery.
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