ReviewVirchows Archiv : an international journal of pathology2023
Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Review in Virchows Archiv : an international journal of pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Potential role of breast MRI to identify patients with high-risk lesions who might avoid surgery: a systematic review and meta-analysis.European radiology · 2026Pooled it
- ESR Essentials: diagnostic work-up in patients with symptomatic breast disease-practice recommendations by the European Society of Breast Imaging.European radiology · 2025Guideline
- Vacuum-assisted excision: a safe minimally invasive option for benign phyllodes tumor diagnosis and treatment-a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Budget Impact Analysis of Vacuum-Assisted Excision Versus Surgical Excision for the Assessment of Breast Lesions of Uncertain Malignant Potential in Italy.PharmacoEconomics - open · 2026Article
- Post-VABB Cavity-Targeted Avidin-Pretargeted [Cancers · 2026Article
- Article
- Management of high-risk (B3) breast lesions in symptomatic practice: evidence review and practical recommendations for multidisciplinary care.Virchows Archiv : an international journal of pathology · 2026Review
- Upgrade and downgrade rates of fibroepithelial lesions in a B3 lesion cohort: a 15-year analysis from a university hospital.The British journal of radiology · 2026Article
- Risk of malignancy after diagnosis of radial sclerosing lesion without atypia.Breast cancer research and treatment · 2026Observational
- An NLP-Driven Framework for Automated Radiology-Pathology Concordance Assessment in Breast Biopsy.Diagnostics (Basel, Switzerland) · 2026Article
- Postoperative complications after vacuum-assisted excision of benign breast tumors and their associated risk factors.Medicine · 2026Article
- Value of ultrasound-guided vacuum-assisted excision in the treatment of non-malignant breast nodules diagnosed as BI-RADS 4A or higher by ultrasound.Gland surgery · 2026Article
- Intraductal papilloma of the breast: low risk, but handle with care.La Radiologia medica · 2026Article
- Papillary lesions of breast on core-needle biopsy: Factors associated with malignant upgrade on surgical excision.Journal of clinical imaging science · 2026Article
- Diagnostic Performance of Artificial Intelligence in Predicting Malignant Upgrade of B3 Breast Lesions: Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- A systematic review and meta-analysis of imaging characteristics and upgrade rates in noninvasive lobular neoplasia of the breast.European journal of radiology open · 2025Article
- High-Risk Breast Lesions on Core Biopsy: Rates of Upgrade and Management Recommendations.Surgical pathology clinics · 2025Review
- Veiled in Gynecomastia: A B3 breast lesion in a male patient with subsequent "upgrade" to invasive malignancy.Radiology case reports · 2025Article
- Variation in Pathological Appearance Across Repeated Sampling from Probably Benign Breast Lesions.Biomedicines · 2025Article
- Breast Lesions of Uncertain Malignant Potential and Risk of Breast Cancer Development: A Single-Center Experience on 10,531 Consecutive Biopsies.Medicina (Kaunas, Lithuania) · 2025Article
Corrections and comments
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Authors and funding
34 authors at 20 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heterogeneous group of B3 lesions in the breast harbors lesions with different malignant potential and progression risk. As several studies about B3 lesions have been published since the last Consensus in 2018, the 3rd International Consensus Conference discussed the six most relevant B3 lesions (atypical ductal hyperplasia (ADH), flat epithelial atypia (FEA), classical lobular neoplasia (LN), radial scar (RS), papillary lesions (PL) without atypia, and phyllodes tumors (PT)) and made recommendations for diagnostic and therapeutic approaches. Following a presentation of current data of each B3 lesion, the international and interdisciplinary panel of 33 specialists and key opinion leaders voted on the recommendations for further management after core-needle biopsy (CNB) and vacuum-assisted biopsy (VAB). In case of B3 lesion diagnosis on CNB, OE was recommended in ADH and PT, whereas in the other B3 lesions, vacuum-assisted excision was considered an equivalent alternative to OE. In ADH, most panelists (76%) recommended an open excision (OE) after diagnosis on VAB, whereas observation after a complete VAB-removal on imaging was accepted by 34%. In LN, the majority of the panel (90%) preferred observation following complete VAB-removal. Results were similar in RS (82%), PL (100%), and FEA (100%). In benign PT, a slim majority (55%) also recommended an observation after a complete VAB-removal. VAB with subsequent active surveillance can replace an open surgical intervention for most B3 lesions (RS, FEA, PL, PT, and LN). Compared to previous recommendations, there is an increasing trend to a de-escalating strategy in classical LN. Due to the higher risk of upgrade into malignancy, OE remains the preferred approach after the diagnosis of ADH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.