Evidence map›Paper›PMID 37330290›Full record

ArticleJournal of molecular biology2023

Cryo-EM Structures of Chronic Traumatic Encephalopathy Tau Filaments with PET Ligand Flortaucipir.

Yang Shi, Bernardino Ghetti, Michel Goedert, Sjors H W Scheres

Open access · hybridAbstract read
In one paragraph

Article in Journal of molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. FibrilPaint to determine the length of Tau amyloids in fluids.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Primary age-related tauopathy.Acta neuropathologica · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Targeted protein degradation with bifunctional molecules as a novel therapeutic modality for Alzheimer's disease & beyond.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  13. Article
  14. Review
  15. A Cooperative Model for Symmetric Ligand Binding to Protein Fibrils.bioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Binding adaptability of chemical ligands to polymorphic α-synuclein amyloid fibrils.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Review
  19. Docking for Molecules That Bind in a Symmetric Stack with SymDOCK.Journal of chemical information and modeling · 2024
    Article
  20. Docking for molecules that bind in a symmetric stack with SymDOCK.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Yang ShiMedical Research Council Laboratory of Molecular Biology, Cambridge, UK. Electronic address: yshi22@zju.edu.cn.
Bernardino GhettiDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: https://twitter.com/GhettiBernardi1.
Michel GoedertMedical Research Council Laboratory of Molecular Biology, Cambridge, UK. Electronic address: mg@mrc-lmb.cam.ac.uk.
Sjors H W ScheresMedical Research Council Laboratory of Molecular Biology, Cambridge, UK. Electronic address: scheres@mrc-lmb.cam.ac.uk.
Medical Research Council · GBIndiana University – Purdue University Indianapolis · US

Funding

Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
Medical Research Council MC_U105184291Medical Research Council MC_UP_A025_1013NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG072976
6 · The paper itself

Abstract

Positron emission tomography (PET) imaging allows monitoring the progression of amyloid aggregation in the living brain. [

Indexed as

Alzheimer DiseaseCarbolinesChronic Traumatic EncephalopathyIntermediate FilamentsRadioactive Tracerstau ProteinsBrainCryoelectron MicroscopyHumansLigandsPositron-Emission TomographyProtein BindingTauopathies7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleCarbolinesLigandsRadioactive Tracerstau ProteinsAmyloidcryo-EMFlortaucipirPET compoundsTau

Identifiers

PMID37330290
PMCPMC7615338
OpenAlexW4380988352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.