Evidence map›Paper›PMID 37329985›Full record

ReviewAdvanced drug delivery reviews2023

Native gastrointestinal mucus: Critical features and techniques for studying interactions with drugs, drug carriers, and bacteria.

Chia-Ming Wang, Matthew T Fernez, Benjamin M Woolston, Rebecca L Carrier

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced drug delivery reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chia-Ming WangDepartment of Bioengineering, Northeastern University, Boston, MA, USA.
Matthew T FernezDepartment of Chemical Engineering, Northeastern University, Boston, MA, USA.
Benjamin M WoolstonDepartment of Chemical Engineering, Northeastern University, Boston, MA, USA.
Rebecca L CarrierDepartment of Bioengineering, Northeastern University, Boston, MA, USA; Department of Chemical Engineering, Northeastern University, Boston, MA, USA; Department of Biology, Northeastern University, Boston, MA, USA. Electronic address: r.carrier@northeastern.edu.
Northeastern University · US

Funding

Impact of Lipids on Compound Absorption: Mechanistic Studies and ModelingR01GM098117 · NIGMS · NORTHEASTERN UNIVERSITY · PI CARRIER, REBECCA L · 2012 to 2021
$3.3M
Engineered Probiotics for Closed-Loop Control of Disease-Associated Gut Metabolites in Gut-On-Chip ModelsR21EB033892 · NIBIB · NORTHEASTERN UNIVERSITY · PI WOOLSTON, BENJAMIN MICHAEL · 2022 to 2024
$636k
NIBIB NIH HHS R21 EB033892NIGMS NIH HHS R01 GM098117
6 · The paper itself

Abstract

Gastrointestinal mucus plays essential roles in modulating interactions between intestinal lumen contents, including orally delivered drug carriers and the gut microbiome, and underlying epithelial and immune tissues and cells. This review is focused on the properties of and methods for studying native gastrointestinal mucus and its interactions with intestinal lumen contents, including drug delivery systems, drugs, and bacteria. The properties of gastrointestinal mucus important to consider in its analysis are first presented, followed by a discussion of different experimental setups used to study gastrointestinal mucus. Applications of native intestinal mucus are then described, including experimental methods used to study mucus as a barrier to drug delivery and interactions with intestinal lumen contents that impact barrier properties. Given the significance of the microbiota in health and disease, its impact on drug delivery and drug metabolism, and the use of probiotics and microbe-based delivery systems, analysis of interactions of bacteria with native intestinal mucus is then reviewed. Specifically, bacteria adhesion to, motility within, and degradation of mucus is discussed. Literature noted is focused largely on applications of native intestinal mucus models as opposed to isolated mucins or reconstituted mucin gels.

Indexed as

Bacterial AdhesionDrug CarriersBacteriaHumansIntestinal MucosaIntestinesMucinsMucusDrug CarriersMucinsBacteria-mucin interactionsFluorescence recovery after photobleachingMucosal drug deliveryMucus barrier propertiesMucus compositionMucus structureMultiple particle trackingNative intestinal mucus

Identifiers

PMID37329985
PMCPMC11184232
OpenAlexW4380758077

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.