Evidence map›Paper›PMID 37329862›Full record

ReviewHearing research2023

Chromodomain helicase DNA binding protein 4 in cell fate decisions.

Alejandra Laureano, Jihyun Kim, Edward Martinez, Kelvin Y Kwan

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hearing research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alejandra LaureanoDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Jihyun KimDepartment of Cell Biology & Neuroscience, Rutgers University, Nelson Labs D250 604 Allison Rd., Piscataway, NJ 08854, USA; Stem Cell Research Center and Keck Center for Collaborative Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
Edward MartinezDepartment of Cell Biology & Neuroscience, Rutgers University, Nelson Labs D250 604 Allison Rd., Piscataway, NJ 08854, USA; Stem Cell Research Center and Keck Center for Collaborative Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
Kelvin Y KwanDepartment of Cell Biology & Neuroscience, Rutgers University, Nelson Labs D250 604 Allison Rd., Piscataway, NJ 08854, USA; Stem Cell Research Center and Keck Center for Collaborative Neuroscience, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: kelvin.kwan@rutgers.edu.
Rutgers, The State University of New Jersey · USHarvard University · US

Funding

The role of transcription factors and chromatin remodeling proteins in spiral ganglion neuron regenerationR01DC015000 · NIDCD · RUTGERS, THE STATE UNIV OF N.J. · PI KWAN, KELVIN Y. · 2016 to 2020
$2.0M
Epigenetic mechanisms of cochlear damage and repairR01DC022483 · NIDCD · RUTGERS, THE STATE UNIV OF N.J. · PI Kelvin Y. Kwan · 2025 to 2026
$1.3M
NIDCD NIH HHS R01 DC015000NIDCD NIH HHS R01 DC022483
6 · The paper itself

Abstract

Loss of spiral ganglion neurons (SGNs) in the cochlea causes hearing loss. Understanding the mechanisms of cell fate transition accelerates efforts that employ directed differentiation and lineage conversion to repopulate lost SGNs. Proposed strategies to regenerate SGNs rely on altering cell fate by activating transcriptional regulatory networks, but repressing networks for alternative cell lineages is also essential. Epigenomic changes during cell fate transitions suggest that CHD4 represses gene expression by altering the chromatin status. Despite limited direct investigations, human genetic studies implicate CHD4 function in the inner ear. The possibility of CHD4 in suppressing alternative cell fates to promote inner ear regeneration is discussed.

Indexed as

Ear, InnerHearing Loss, SensorineuralCell DifferentiationDNA-Binding ProteinsHumansMi-2 Nucleosome Remodeling and Deacetylase ComplexNeuronsSpiral GanglionDNA-Binding ProteinsMi-2 Nucleosome Remodeling and Deacetylase ComplexCHD4Chromatin remodelingChromodomain helicase dna binding proteinEpigeneticsInner ear regeneration

Identifiers

PMID37329862
PMCPMC10463912
OpenAlexW4378839541

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.