ArticleEBioMedicine2023
Infant gut microbiota and environment associate with juvenile idiopathic arthritis many years prior to disease onset, especially in genetically vulnerable children.
Article in EBioMedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Probiotic supplementation increases fecal TLR4 agonists without improving disease activity in juvenile idiopathic arthritis: a randomized placebo-controlled trial.Gut microbes · 2026Trial
- Microbial shifts in early life: the pediatric gut microbiome and its role in health and disease.Gut microbes · 2026Review
- Early-life physical activity and risk of juvenile idiopathic arthritis: a longitudinal ABIS cohort study using a symptom-free baseline design.Pediatric rheumatology online journal · 2026Article
- Recent antibiotic exposure and response to treatment of juvenile idiopathic arthritis: a retrospective cohort study.Arthritis research & therapy · 2026Article
- The gut-joint axis in juvenile idiopathic arthritis.Arthritis research & therapy · 2026Review
- Composition of and changes in faecal microbiota in children diagnosed with oligoarticular juvenile idiopathic arthritis.Frontiers in medicine · 2026Article
- Regional Gastrointestinal Permeability Patterns in Juvenile Idiopathic Arthritis: A Window into Subclinical Inflammation and Microbiota-Driven Disease Mechanisms.Children (Basel, Switzerland) · 2025Article
- One-year follow-up of a short specific carbohydrate diet intervention in children with juvenile idiopathic arthritis: A retrospectively controlled study with focus on medical burden.Clinical rheumatology · 2025Article
- Associations Between the Gut Microbiota and Its Related Metabolic Pathways and Uveitis: A Bidirectional Two-Sample Mendelian Randomization Study.Translational vision science & technology · 2025Article
- MO Oxygen Therapy Prevents Doxorubicin-Induced Cardiotoxicity.Cardiology research and practice · 2025Article
- Exploring nutritional risks of the specific carbohydrate diet: food and nutrient intake in children with juvenile idiopathic arthritis.Journal of nutritional science · 2025Article
- Age-stratification reveals age-specific intestinal microbiota signatures in juvenile idiopathic arthritis.Molecular and cellular pediatrics · 2024Article
- Familial clustering of dysbiotic oral and fecal microbiomes in juvenile dermatomyositis.Scientific reports · 2024Observational
- Prenatal exposure to environmental contaminants and cord serum metabolite profiles in future immune-mediated diseases.Journal of exposure science & environmental epidemiology · 2024Article
- Association of Infant Breastfeeding and Juvenile Spondyloarthritis: A Case-Control Study.The Journal of rheumatology · 2024Article
- Breastfeeding decreases the risk of developing psoriasis through to early adulthood.The British journal of dermatology · 2024Article
- Integrative non-pharmacological care for individuals at risk of rheumatoid arthritis.Rheumatology international · 2024Review
- Causal association of juvenile idiopathic arthritis or JIA-associated uveitis and gut microbiota: a bidirectional two-sample Mendelian randomisation study.Frontiers in immunology · 2024Article
- Association and function analysis of genetic variants and the risk of gestational diabetes mellitus in a southern Chinese population.Frontiers in endocrinology · 2024Article
- Antibiotic exposure in prenatal and early life and risk of juvenile idiopathic arthritis: a nationwide register-based cohort study.RMD open · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe etiology of juvenile idiopathic arthritis (JIA) is poorly understood. This study investigated genetic and environmental factors and infant gut microbiota in a prospective birth cohort to assess disease risk.
methodsData was collected from the All Babies in Southeast Sweden (ABIS) population-based cohort (n = 17,055), 111 of whom later acquired JIA (ABIS
findingsABIS
interpretationMicrobial dysregulation in infancy may trigger or accelerate JIA development. Environmental risk factors have a stronger impact on genetically predisposed children. This study is the first to implicate microbial dysregulation in JIA at such an early age, with many bacterial taxa associated with risk factors. These findings provide opportunities for intervention or early screening and offer new insights into JIA pathogenesis.
fundingBarndiabetesfonden; Swedish Council for Working Life and Social Research; Swedish Research Council; Östgöta Brandstodsbolag; Medical Research Council of Southeast Sweden; JDRF-Wallenberg Foundation; Linköping.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.