SynthesisHernia : the journal of hernias and abdominal wall surgery2023
Systematic review and meta-analysis of the pre-operative application of botulinum toxin for ventral hernia repair.
Synthesis in Hernia : the journal of hernias and abdominal wall surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Preoperative botulinum toxin for complex abdominal wall reconstruction: a meta-analysis of propensity-score matched studies with trial sequential analysis.Hernia : the journal of hernias and abdominal wall surgery · 2025Pooled it
- Basal Tone, Muscle Memory and Denervation: Pathophysiological Foundations of Abdominal Wall Hernia Development and Recovery.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Metabolism, Morphology and Function of the Anterior Abdominal Wall Musculature in Ventral Hernias and After Repair: A Narrative Review and Research Agenda.Journal of personalized medicine · 2026Review
- Electromyographic and tomographic muscle changes after botulinum toxin administration through either 3 or 8 injection points in patients with large midline ventral hernias: a superiority study.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- The relationship between peak pressure and pulmonary complications in complex abdominal wall reconstruction.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- Ultrasound-Guided Botulinum Toxin A as an Adjunct to Intraoperative Fascial Traction in Incisional Hernia Repair: Registry-Based Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Ultrasound alone is sufficient: no added value of electromyography in botulinum toxin prehabilitation for complex ventral hernias?Hernia : the journal of hernias and abdominal wall surgery · 2026Observational
- Long-Term Outcomes of Preoperative Botulinum Toxin Use in Abdominal Wall Reconstruction: A Propensity-Matched Analysis of More Than 5000 Patients Over 5 Years.Aesthetic surgery journal. Open forum · 2026Article
- Minimally Invasive Approach Utilizing Linear Stapler for Midline Incisional Hernia: Stapler Repair Technique.Annals of gastroenterological surgery · 2025Article
- Effectiveness of pre-operative chemical component separation with computed tomography-guided intramuscular injection of OnabotulinumtoxinA in outcomes of large complex incisional ventral abdominal hernia repair: a propensity score-weighted comparative analysis.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Follow-up of complex hernia repair with intraoperative fascial traction.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Does sarcopenia have a negative impact on the efficacy of botulinum toxin A in the prehabilitation of patients undergoing incisional hernia repair? A multicentric retrospective study.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Preoperative Botulinum Toxin for Complex Diaphragmatic Paralysis: A Case Series.Journal of abdominal wall surgery : JAWS · 2025Article
- Preoperative botolinum toxin A (BTA) and intraoperative fascial traction (IFT) in the management of complex abdominal wall hernias.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- [The use of botulinum toxin in hernia surgery: results of a survey in certified hernia centers].Chirurgie (Heidelberg, Germany) · 2024Article
- Achieving fascial closure with preoperative botulinum toxin injections in abdominal wall reconstruction: outcomes from a high-volume center.Updates in surgery · 2024Article
- Open intraperitoneal onlay mesh repair with anterior component separation as a bail-out procedure in the management of complex hernias.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Peritoneal flap technique for abdominal wall expansion in the management of complex ventral hernias: a multicentre study from India.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Intra-abdominal hypertension and compartment syndrome after complex hernia repair.Hernia : the journal of hernias and abdominal wall surgery · 2024Review
- Limitations of Transversus Abdominis Release (TAR)-Additional Bridging of the Posterior Layer And/Or Anterior Fascia Is the Preferred Solution in Our Clinical Routine If Primary Closure is Not Possible.Journal of abdominal wall surgery : JAWS · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSurgical repair of large hernia defects requires detailed pre-operative planning, particularly in cases with loss of domain. This situation often hampers mid-line reconstruction, even after component separation, when the size of the hernia is disproportional to the volume of the abdominal area. In this case, other strategies may be needed to place the viscera back into the abdominal cavity after reducing the hernia sac. The administration of botulinum toxin prior to the surgical procedure has been indicated as an adjunct for more complex cases. This results in stretching of the lateral musculature of the abdomen, allowing midline approximation. In addition, the application of botulinum toxin alone has been investigated as a means of downstaging in the management of ventral hernias, thereby precluding component separation and enabling primary closure of the midline by placement of mesh within the retromuscular space using the Rives Stoppa technique.
methodsSystematic review of the literature for observational studies involving patients undergoing pre-operative application of botulinum toxin for ventral hernia repair was conducted according to the PRISMA guidelines.
resultsAdvance of the lateral musculature of the abdomen by an average of 4.11 cm with low heterogeneity, as well as low rates of surgical site infection (SSI), surgical site occurrences (SSO) and recurrence, was shown.
conclusionPre-operative application of botulinum toxin for ventral hernia repair promoted an increase in the length of the lateral musculature of the abdomen which can help improve the outcomes of morbidity and recurrence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.