ArticlePhysical review. E2023
Kinetic relaxation of giant vesicles validates diffusional softening in a binary lipid mixture.
Article in Physical review. E, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The multiple sclerosis drug fingolimod induces pore-like membrane defects, contributing to its antimicrobial activity.The Journal of biological chemistry · 2026Article
- SurFlex microscopy: Measuring flexibility of surface-tethered biomolecules.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Curvature fluctuations of fluid vesicles reveal hydrodynamic dissipation within the bilayer.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Softening in Two-Component Lipid Mixtures by Spontaneous Curvature Variance.The journal of physical chemistry. B · 2024Article
- Efficient calculation of orientation-dependent lipid dynamics from membrane simulations.bioRxiv : the preprint server for biology · 2024Article
- Softening in two-component lipid mixtures by spontaneous curvature variance.bioRxiv : the preprint server for biology · 2023Article
- Nonuniversal impact of cholesterol on membranes mobility, curvature sensing and elasticity.Nature communications · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The stiffness of biological membranes determines the work required by cellular machinery to form and dismantle vesicles and other lipidic shapes. Model membrane stiffness can be determined from the equilibrium distribution of giant unilamellar vesicle surface undulations observable by phase contrast microscopy. With two or more components, lateral fluctuations of composition will couple to surface undulations depending on the curvature sensitivity of the constituent lipids. The result is a broader distribution of undulations whose complete relaxation is partially determined by lipid diffusion. In this work, kinetic analysis of the undulations of giant unilamellar vesicles made of phosphatidylcholine-phosphatidylethanolamine mixtures validates the molecular mechanism by which the membrane is made 25% softer than a single-component one. The mechanism is relevant to biological membranes, which have diverse and curvature-sensitive lipids.
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