Evidence map›Paper›PMID 37328859›Full record

ArticleBMC musculoskeletal disorders2023

The effect of calcium supplementation on calcium and bone metabolism during load carriage in women: protocol for a randomised controlled crossover trial.

Charlotte V Coombs, Sophie L Wardle, Rukshana Shroff, Anton Eisenhauer, Jonathan C Y Tang, William D Fraser, Julie P Greeves, Thomas J O'Leary

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04823156 (The Effect of Calcium Intake on Calcium and Bone Metabolism During Load Carriage in Women), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04823156 naunknown statusnot on this map

The Effect of Calcium Intake on Calcium and Bone Metabolism During Load Carriage in Women: a Randomised Controlled Trial

TypeinterventionalSponsorArmy Health Branch, British ArmyRan2022 to 2023Enrolled40ConditionsCalcium DeficiencyArmsCalcium
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Charlotte V CoombsArmy Health and Performance Research, Army Headquarters, Andover, SP11 8HT, UK.
Sophie L WardleArmy Health and Performance Research, Army Headquarters, Andover, SP11 8HT, UK.
Rukshana ShroffRenal Unit, UCL Great Ormond Street Hospital for Children NHS Foundation Trust and Institute of Child Health, London, UK.
Anton EisenhauerGEOMAR Helmholtz Centre for Ocean Research, Kiel, Germany.
Jonathan C Y TangNorwich Medical School, University of East Anglia, Norwich, UK.
William D FraserNorwich Medical School, University of East Anglia, Norwich, UK.
Julie P GreevesArmy Health and Performance Research, Army Headquarters, Andover, SP11 8HT, UK.
Thomas J O'LearyArmy Health and Performance Research, Army Headquarters, Andover, SP11 8HT, UK. thomas.oleary100@mod.gov.uk.
University of East Anglia · GBGEOMAR Helmholtz Centre for Ocean Research Kiel · DEUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMilitary field exercises are characterised by high volumes of exercise and prolonged periods of load carriage. Exercise can decrease circulating serum calcium and increase parathyroid hormone and bone resorption. These disturbances to calcium and bone metabolism can be attenuated with calcium supplementation immediately before exercise. This randomised crossover trial will investigate the effect of calcium supplementation on calcium and bone metabolism, and bone mineral balance, during load carriage exercise in women.

methodsThirty women (eumenorrheic or using the combined oral contraceptive pill, intrauterine system, or intrauterine device) will complete two experimental testing sessions either with, or without, a calcium supplement (1000 mg). Each experimental testing session will involve one 120 min session of load carriage exercise carrying 20 kg. Venous blood samples will be taken and analysed for biochemical markers of bone resorption and formation, calcium metabolism, and endocrine function. Urine will be collected pre- and post-load carriage to measure calcium isotopes for the calculation of bone calcium balance. DISCUSSION: The results from this study will help identify whether supplementing women with calcium during load carriage is protective of bone and calcium homeostasis.

trial registrationNCT04823156 (clinicaltrials.gov).

Indexed as

Bone ResorptionCalciumBiomarkersCross-Over StudiesDietary SupplementsFemaleHumansParathyroid HormoneRandomized Controlled Trials as TopicBiomarkersCalciumParathyroid HormoneBone metabolismCalciumExerciseLoad carriageSupplement

Identifiers

PMID37328859
PMCPMC10273742
OpenAlexW4380986934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.