Evidence map›Paper›PMID 37328833›Full record

ArticleFluids and barriers of the CNS2023

Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1.

Ryann M Fame, Huixin Xu, Aja Pragana, Maria Lehtinen

Open access · goldAbstract read
In one paragraph

Article in Fluids and barriers of the CNS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Molecular hallmarks of hydrocephalus.Science translational medicine · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Ryann M Fame *Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Huixin Xu *Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Aja PraganaDepartment of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Maria LehtinenDepartment of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA. maria.lehtinen@childrens.harvard.edu.
Boston Children's Hospital · USHarvard University · USStanford University · US

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Control of neural stem cells by the nascent cerebrospinal fluidR01NS088566 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI LEHTINEN, MARIA · 2014 to 2024
$5.5M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI CHEN, CHINFEI · 2016 to 2020
$5.2M
Targeting the Choroid Plexus-Cerebrospinal Fluid System to Treat Post-Hemorrhagic HydrocephalusR01NS129823 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI MARIA LEHTINEN · 2023 to 2026
$2.6M
Pediatric Pathology Translational ResearchT32HL110852 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI FLEMING, MARK D · 2012 to 2017
$1.4M
NICHD NIH HHS P50 HD105351NICHD NIH HHS U54 HD090255NIH HHS HL110852NIH HHS NS088566NINDS NIH HHS R01 NS088566NINDS NIH HHS R01 NS129823
6 · The paper itself

Abstract

Regulation of the volume and electrolyte composition of the cerebrospinal fluid (CSF) is vital for brain development and function. The Na-K-Cl co-transporter NKCC1 in the choroid plexus (ChP) plays key roles in regulating CSF volume by co-transporting ions and mediating same-direction water movements. Our previous study showed ChP NKCC1 is highly phosphorylated in neonatal mice as the CSF K

Indexed as

Choroid PlexusPotassiumSolute Carrier Family 12, Member 2AnimalsCerebral CortexCerebral VentriclesCerebrospinal FluidFemaleMicePregnancyRatsPotassiumSlc12a2 protein, mouseSlc12a2 protein, ratSolute Carrier Family 12, Member 2AAVBrain developmentCerebral cortexCerebrospinal fluidChoroid plexusConditional knockoutGenome editingNKCC1Potassium clearance

Identifiers

PMID37328833
PMCPMC10276483
OpenAlexW4380985527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.