Evidence map›Paper›PMID 37328778›Full record

ArticleBMC oral health2023

The effect of carbodiimide on push-out bond strength of fiber posts and endogenous enzymatic activity.

Uros Josic, Claudia Mazzitelli, Tatjana Maravic, Allegra Comba, Milena Cadenaro, Ivana Radovic, Maicon Sebold, Gianluca Turco, Lorenzo Breschi, Annalisa Mazzoni

Open access · goldAbstract read
In one paragraph

Article in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Evolution of Dental Resin Adhesives-A Comprehensive Review.Journal of functional biomaterials · 2025
    Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Uros JosicDepartment for Biomedical and Neuromotor Sciences, Dental Clinic, DIBINEM, University of Bologna, Via San Vitale 59, Bologna, 40125, Italy.
Claudia MazzitelliDepartment for Biomedical and Neuromotor Sciences, Dental Clinic, DIBINEM, University of Bologna, Via San Vitale 59, Bologna, 40125, Italy.
Tatjana MaravicDepartment for Biomedical and Neuromotor Sciences, Dental Clinic, DIBINEM, University of Bologna, Via San Vitale 59, Bologna, 40125, Italy.
Allegra CombaDepartment of Surgical Sciences, University of Turin, Turin, Italy.
Milena CadenaroDepartment of Medical Sciences, University of Trieste, Trieste, Italy.
Ivana RadovicClinic for Paediatric and Preventive Dentistry, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
Maicon SeboldDepartment of Restorative Dentistry, Operative Dentistry Division, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil.
Gianluca TurcoDepartment of Medical Sciences, University of Trieste, Trieste, Italy.
Lorenzo BreschiDepartment for Biomedical and Neuromotor Sciences, Dental Clinic, DIBINEM, University of Bologna, Via San Vitale 59, Bologna, 40125, Italy.
Annalisa MazzoniDepartment for Biomedical and Neuromotor Sciences, Dental Clinic, DIBINEM, University of Bologna, Via San Vitale 59, Bologna, 40125, Italy. annalisa.mazzoni@unibo.it.
University of Bologna · ITUniversity of Trieste · ITUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Belgrade · RSUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the effect of 0.3 M 1-ethyl-3(3-dimethylaminopropyl) carbodiimide (EDC) aqueous solution pretreatment on push-out bond strength (PBS) and matrix-metalloproteinases (MMPs) activity within radicular dentin when different post cementation strategies were employed.

methodsOne hundred and twenty monoradicular human teeth were endodontically treated and randomly divided into six groups, depending on the cementation strategy and root dentin pretreatment (n = 20): EAR: cementation with an etch-and-rinse adhesive (LuxaBond Total Etch, DMG) and resin cement (LuxaCore Z Dual, DMG); EAR/EDC: 1 min EDC pretreatment after etching + EAR; SE: cementation with a self-etch primer (Multilink Primer, Ivoclar Vivadent) and corresponding cement (Multilink Automix, Ivoclar Vivadent); SE/EDC: self-etch primer + EDC pretreatment + SE; SA: cementation with a universal self-adhesive cement (RelyX Universal, 3 M); SA/EDC: EDC pretreatment + SA. Slices were submitted to PBS test and interfacial nanoleakage evaluation 24 h after cementation or after thermocycling (40.000 cycles, 5-55 °C). To investigate the effect of EDC on MMPs activity, 4 additional first maxillary premolars per group were processed for in situ zymography analysis. Multivariate ANOVA and post hoc Tukey tests were used to analyze PBS values. The data from in situ zymography were analyzed with Kruskal-Wallis test and Dunn's pairwise multiple comparison procedures (α = 0.05).

resultsThe variables "EDC pretreatment", "root region" and "thermocycling" significantly influenced PBS (p < 0.05), while the variable "cementation strategy" had no influence (p > 0.05). Thermocycling significantly reduced PBS in SE and SA groups (p < 0.05). EDC was effective in preserving PBS after artificial aging. EDC pretreatment significantly reduced enzymatic activity at baseline in EAR and SE groups, and in SA group after thermocycling (p < 0.05).

conclusionsThe use of EDC prevents the reduction of bond-strength values after artificial aging and silences endogenous enzymatic activity within radicular dentin when different cementation strategies were employed.

Indexed as

Dental BondingAcrylic ResinsCarbodiimidesComposite ResinsDentinHumansMaterials TestingMatrix MetalloproteinasesPolyurethanesResin CementsAcrylic ResinsCarbodiimidesComposite ResinsMatrix MetalloproteinasesPolyurethanesResin CementsVivadentCarbodiimideIn situ zymographyMMPsPush-out bond strengthRadicular dentin

Identifiers

PMID37328778
PMCPMC10276460
OpenAlexW4380992569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.