Evidence map›Paper›PMID 37328659›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2023

Concurrent high-grade glioma with cavernous malformations and pathogenic variants in PDCD10 and SMARCA4.

Hannah Glanz, Sudarshawn N Damodharan, Kelcy Smith-Simmer, Jeffrey Helgager, Diane Puccetti

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In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hannah Glanz *Department of Pediatrics, School of Medicine & Public Health, University of Wisconsin, Madison, WI, USA.
Sudarshawn N Damodharan *Division of Pediatric Hematology, Oncology and Bone Marrow Transplant, Department of Pediatrics, School of Medicine & Public Health, University of Wisconsin, UW Carbone Cancer Center, 600 Highland Ave, Madison, WI, 53792, USA. sdamodharan@uwhealth.org.
Kelcy Smith-SimmerMaster of Genetic Counselor Studies, Department of Pediatrics, School of Medicine & Public Health, University of Wisconsin, UW Carbone Cancer Center, Madison, WI, USA.
Jeffrey HelgagerDepartment of Pathology, School of Medicine & Public Health, University of Wisconsin, Madison, WI, USA.
Diane PuccettiDivision of Pediatric Hematology, Oncology and Bone Marrow Transplant, Department of Pediatrics, School of Medicine & Public Health, University of Wisconsin, UW Carbone Cancer Center, 600 Highland Ave, Madison, WI, 53792, USA.
University of Wisconsin Carbone Cancer Center · USUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The co-occurrence of multiple disease processes can pose diagnostic challenges. We report an unusual case of a patient found to have co-occurrences of an IDH1-mutant high-grade glioma along with cerebral cavernous malformations and pathogenic germline variants in PDCD10 and SMARCA4. Somatic testing was done on the tumor and identified a SMARCA4 and two TP53 variants. Within the literature, little is known about the association of high-grade gliomas with these germline variants. Such findings furthermore not only inform complex diagnoses, but have the potential to play a crucial role in the ongoing care of a patient.

Indexed as

Brain NeoplasmsGliomaApoptosis Regulatory ProteinsDNA HelicasesGerm-Line MutationHumansIsocitrate DehydrogenaseMembrane ProteinsMutationNuclear ProteinsProto-Oncogene ProteinsTranscription FactorsApoptosis Regulatory ProteinsDNA HelicasesIsocitrate DehydrogenaseMembrane ProteinsNuclear ProteinsPDCD10 protein, humanProto-Oncogene ProteinsSMARCA4 protein, humanTranscription FactorsCavernous malformationsGenetic variantsHigh-grade gliomaIDH1SMARCA4

Identifiers

PMID37328659
OpenAlexW4380875481

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.