ArticleNature communications2023
Deep optoacoustic localization microangiography of ischemic stroke in mice.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 53 citations in OpenAlex.
- Optoacoustic brain imaging: A systematic review and field mapping.Photoacoustics · 2026Article
- Integrated device for optoacoustically-guided ultrasound surgery.Nature communications · 2026Article
- Multiplexed optoacoustic tracking and magnetic actuation of labeled blood cells in living mice.Science advances · 2026Article
- Noninvasive whole-brain imaging of glymphatic dynamics.Science advances · 2026Article
- Data-driven super-resolution optoacoustic imaging via physically encoded signal acquisition.Research square · 2026Article
- Three-dimensional microangiography of the mouse brain using super-resolution ultrasound and optoacoustic imaging with a spherical array transducer.Photoacoustics · 2026Article
- Multiscale photoacoustic imaging of stroke in preclinical models and future directions toward clinical translation [Invited].Biomedical optics express · 2026Review
- Double-helix optical point spread function enables real-time mesoscopic 3D functional microangiography in the living mouse brain and skull.Nature communications · 2026Article
- Inducing and monitoring photothrombotic stroke in anesthetic neuroprotection-free mice using functional photoacoustic microscopy.Neurophotonics · 2026Article
- Super-resolution functional photoacoustic microscopy via label-free cell tracking.Light, science & applications · 2026Article
- Noninvasive photoacoustic computed mesoscopy for longitudinal brain imaging.Science advances · 2026Article
- Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Optoacoustic-Guided Magnetic Microrobot Platform for Precision Drug Delivery.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Laser Ultrasound Super-Resolution Imaging for Multi-Parametric Non-Invasive Volumetric Characterization of Brain Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Upconversion Nanoparticle-Covalent Organic Framework Core-shell Particles as Therapeutic Microrobots Trackable With Optoacoustic Imaging.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Toward noninvasive optoacoustic imaging of whole-heart dynamics in mice.Light, science & applications · 2025Article
- Noninvasive Optoacoustic Imaging of Oxygen Saturation Reveals Hypoxic Hematopoietic Bone Marrow during Systemic Inflammation.Nano letters · 2025Article
- Imaging the brain by traversing the skull with light and sound.Nature biomedical engineering · 2025Review
- Multiparametric super-resolution optoacoustic imaging with ICG-tagged microbubbles.Materials today. Bio · 2025Article
- Dual-modal super-resolution ultrasound and NIR-II fluorescence imaging of ischemic stroke with ICG-doped porous PLGA microspheres.Materials today. Bio · 2025Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
Abstract
Super-resolution optoacoustic imaging of microvascular structures deep in mammalian tissues has so far been impeded by strong absorption from densely-packed red blood cells. Here we devised 5 µm biocompatible dichloromethane-based microdroplets exhibiting several orders of magnitude higher optical absorption than red blood cells at near-infrared wavelengths, thus enabling single-particle detection in vivo. We demonstrate non-invasive three-dimensional microangiography of the mouse brain beyond the acoustic diffraction limit (<20 µm resolution). Blood flow velocity quantification in microvascular networks and light fluence mapping was also accomplished. In mice affected by acute ischemic stroke, the multi-parametric multi-scale observations enabled by super-resolution and spectroscopic optoacoustic imaging revealed significant differences in microvascular density, flow and oxygen saturation in ipsi- and contra-lateral brain hemispheres. Given the sensitivity of optoacoustics to functional, metabolic and molecular events in living tissues, the new approach paves the way for non-invasive microscopic observations with unrivaled resolution, contrast and speed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.