ArticleNature communications2023
Tyrosine residues initiated photopolymerization in living organisms.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- In Situ Synthesis of Covalent Organic Frameworks Inside Cells for Triggering Ferroptosis and Immunotherapy.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Photo-excited extracellular electron transfer of electroactive microorganism triggers RAFT polymerization.Nature communications · 2025Article
- Glucose Oxidase Initiates Radical Polymerizations by Direct Electron Transfer to Monomers.Biomacromolecules · 2025Article
- Recent progress of artificial cells in structure design, functionality and the prospects in food biotechnology.Materials today. Bio · 2025Review
- Bacteria-Mediated Intracellular Radical Polymerizations.Journal of the American Chemical Society · 2025Article
- Organelle-like structural evolution of coacervate droplets induced by photopolymerization.Nature communications · 2025Article
- Light-Controlled Intracellular Synthesis of Poly(luciferin) Polymers Induces Cell Paraptosis.Journal of the American Chemical Society · 2025Article
- Catalyzing PET-RAFT Polymerizations Using Inherently Photoactive Zinc Myoglobin.Angewandte Chemie (International ed. in English) · 2025Article
- A synergistic herbal formulation targetingFrontiers in microbiology · 2025Article
- Engineering Cyborg Pathogens through Intracellular Hydrogelation.ACS synthetic biology · 2024Article
- Applications of synthetic polymers directed toward living cells.Nature synthesis · 2024Article
- Scandium Ion-Promoted Electron-Transfer Disproportionation of 2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-Oxide (PTIOInternational journal of molecular sciences · 2024Article
- Synthetic control of living cells by intracellular polymerization.Trends in biotechnology · 2024Review
- Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy.Nature communications · 2024Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Towards intracellular engineering of living organisms, the development of new biocompatible polymerization system applicable for an intrinsically non-natural macromolecules synthesis for modulating living organism function/behavior is a key step. Herein, we find that the tyrosine residues in the cofactor-free proteins can be employed to mediate controlled radical polymerization under 405 nm light. A proton-coupled electron transfer (PCET) mechanism between the excited-state TyrOH* residue in proteins and the monomer or the chain transfer agent is confirmed. By using Tyr-containing proteins, a wide range of well-defined polymers are successfully generated. Especially, the developed photopolymerization system shows good biocompatibility, which can achieve in-situ extracellular polymerization from the surface of yeast cells for agglutination/anti-agglutination functional manipulation or intracellular polymerization inside yeast cells, respectively. Besides providing a universal aqueous photopolymerization system, this study should contribute a new way to generate various non-natural polymers in vitro or in vivo to engineer living organism functions and behaviours.
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