Evidence map›Paper›PMID 37328388›Full record

ArticleTrends in biochemical sciences2023

Understanding chaperone specificity: evidence for a 'client code'.

Siddhi Omkar, Ainella Rysbayeva, Andrew W Truman

Open access · greenAbstract read
In one paragraph

Article in Trends in biochemical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Siddhi OmkarDepartment of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Ainella RysbayevaDepartment of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Andrew W TrumanDepartment of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, NC 28223, USA. Electronic address: atruman1@uncc.edu.
University of North Carolina at Charlotte · US

Funding

Understanding the reciprocal regulation between Hsp70 and the DNA damage response.R01GM139885 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI TRUMAN, ANDREW WILLIAM · 2021 to 2024
$1.4M
Understanding ER chaperone-mediated RNR regulationR15GM139059 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI TRUMAN, ANDREW WILLIAM · 2020 to 2020
$440k
NIGMS NIH HHS R01 GM139885NIGMS NIH HHS R15 GM139059
6 · The paper itself

Abstract

The interactions of molecular chaperones with clients can be regulated by chaperone post-translational modification (PTMs) collectively known as the 'chaperone code'. What is less understood is how PTMs on client proteins may impact chaperone-client interactions. In this forum, we discuss the possibility of a 'client code'.

Indexed as

HSP90 Heat-Shock ProteinsMolecular ChaperonesHSP70 Heat-Shock ProteinsHumansProtein BindingProtein Processing, Post-TranslationalHSP70 Heat-Shock ProteinsHSP90 Heat-Shock ProteinsMolecular ChaperoneschaperonesclientHsp70Hsp90phosphorylationpost-translational modification

Identifiers

PMID37328388
PMCPMC10470250
OpenAlexW4380742409

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.