ArticleJournal of advanced research2024
Inhibition of oxidative stress-induced epithelial-mesenchymal transition in retinal pigment epithelial cells of age-related macular degeneration model by suppressing ERK activation.
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Article in Journal of advanced research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38citing papers in PubMed
12.3field-weighted citation impact, top 1% of its field
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Who cites it
38 citing papers in PubMed, 51 citations in OpenAlex.
- Psalmotoxin-1, a novel TRPM2 channel antagonist, reduces age-related macular degeneration-caused mitochondrial oxidative damage and apoptosis in human retinal pigment epithelial (ARPE-19) cells.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Tetrahydrocurcumin Attenuates NaIOAntioxidants (Basel, Switzerland) · 2026Article
- Chlorogenic acid mitigates calcium oxalate monohydrate crystal-induced epithelial-to-mesenchymal transition in renal epithelial cells via suppression of HSP60 expression and p38 signaling.Cellular & molecular biology letters · 2026Article
- A sequential dual-drug delivery system for multi-target inhibition of subretinal fibrosis.Journal of nanobiotechnology · 2026Article
- Pyrroloquinoline Quinone Protects Against Light-Induced Retinal Damage in Association with the Suppression of c-Fos Signalling.International journal of molecular sciences · 2026Article
- Dynamin-Related Protein 1-Dependent Disruption of Mitochondrial Homeostasis Drives Blue Light-Induced Epithelial-Mesenchymal Transition in Retinal Aging.Aging cell · 2026Article
- Role and regulation of kinases in age-related macular degeneration.Journal of translational medicine · 2026Review
- Cannabidiol Suppresses Glioma Growth and Limits Invasion Partly Through an LOXL2-Associated EMT-Like Program.BioMed research international · 2026Article
- The contribution of ferroptosis to the epithelial-mesenchymal transition phenotype in models of age-related macular degeneration.Frontiers in cell and developmental biology · 2026Article
- SPI1 Promotes TNF-α-Induced Epithelial-Mesenchymal Transition-Like Changes in Retinal Pigment Epithelial Cells: Implications for the Pathogenesis of Age-Related Macular Degeneration.Journal of ophthalmology · 2026Article
- Eriocitrin inhibits sodium iodate-induced cuproptosis and barrier function impairment in retinal pigment epithelium via SIRT7/YAP/ATP7A pathway.Journal of translational medicine · 2025Article
- Desmosome and Hemidesmosome Release via Exosomes from Retinal Pigmented Epithelium - A Precursor to Epithelial-Mesenchymal Transition in Early AMD?Current eye research · 2025Review
- Cannabidiol inhibits TGF-β1-induced epithelial-mesenchymal transition in human conjunctival epithelial cells by interrupting TGF-β/Smad signaling.Scientific reports · 2025Article
- Glycolipids implicated as mediators of clinically visible retinal pigment epithelial migration in age-related macular degeneration.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Molecular Mechanisms of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells: Implications for Age-Related Macular Degeneration (AMD) Progression.Biomolecules · 2025Review
- Exploring Therapeutic Targets for Age-Related Macular Degeneration From Circulating Proteins to Plasma Metabolites in the European Population.Translational vision science & technology · 2025Article
- Liraglutide Attenuates FFA-Induced Retinal Pigment Epithelium Dysfunction via AMPK Activation and Lipid Homeostasis Regulation in ARPE-19 Cells.International journal of molecular sciences · 2025Article
- Therapeutic Potential of Hexahydrocurcumin in the Regeneration and Protection of the Retinal Pigment Epithelium.Pharmaceuticals (Basel, Switzerland) · 2025Review
- TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis.Molecular therapy. Nucleic acids · 2025Article
- Metabolomic Characteristics of Aqueous Humor in Wet Age-Related Macular Degeneration and the Impact of Anti-VEGF Treatment.Investigative ophthalmology & visual science · 2025Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Ya-Chi YangDepartment of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan; College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Yueh ChienDepartment of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan; College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Aliaksandr A YarmishynDepartment of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan; College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Lee-Yieng LimDepartment of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan.
Hao-Yu TsaiDepartment of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan; Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Wen-Chuan KuoInstitute of Biophotonics, College of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Ping-Hsing TsaiDepartment of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan; College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Sheng-Hsien YangInstitute of Biophotonics, College of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Shao-I HongDepartment of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan; Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Shih-Jen ChenCollege of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112201, Taiwan.
De-Kuang HwangCollege of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112201, Taiwan.
Yi-Ping YangDepartment of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan; College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. Electronic address: molly0103@gmail.com.
Shih-Hwa ChiouDepartment of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan; College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112201, Taiwan; Genomic Research Center, Academia Sinica, Taipei 115024, Taiwan. Electronic address: shchiou@vghtpe.gov.tw.
National Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TW
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEpithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is related to the pathogenesis of various retinopathies including age-related macular degeneration (AMD). Oxidative stress is the major factor that induces degeneration of RPE cells associated with the etiology of AMD.
objectivesSodium iodate (NaIO
methodsThe EMT characteristics in NaIO
resultsWe found that NaIO
conclusionsERK is a crucial regulator of multiple NaIO
Indexed as
Disease Models, AnimalEpithelial-Mesenchymal TransitionIodatesMacular DegenerationOxidative StressReactive Oxygen SpeciesRetinal Pigment EpitheliumAnimalsCell LineEpithelial CellsErbB ReceptorsExtracellular Signal-Regulated MAP KinasesHumansMAP Kinase Signaling SystemMiceMice, Inbred C57BLErbB ReceptorsExtracellular Signal-Regulated MAP KinasesIodatesReactive Oxygen Speciessodium iodateCalcium signalingEpithelial growth factor receptorExtracellular signal-regulated kinaseFR180204Reactive oxygen speciesRetinopathy
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.