Evidence map›Paper›PMID 37327878›Full record

ArticleAntiviral research2023

Efficacy of an isoxazole-3-carboxamide analog of pleconaril in mouse models of Enterovirus-D68 and Coxsackie B5.

Thomas R Lane, Jianing Fu, Barbara Sherry, Bart Tarbet, Brett L Hurst, Olga Riabova, Elena Kazakova, Anna Egorova, Penny Clarke, J Smith Leser and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antiviral research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

Thomas R LaneCollaborations Pharmaceuticals Inc., Raleigh, NC, USA.
Jianing FuDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Barbara SherryDepartment of Molecular Biomedical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA.
Bart TarbetInstitute for Antiviral Research, Utah State University, Logan, UT, USA; Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA.
Brett L HurstInstitute for Antiviral Research, Utah State University, Logan, UT, USA; Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA.
Olga RiabovaResearch Center of Biotechnology RAS, 33-1 Leninsky prospect, 119071, Moscow, Russia.
Elena KazakovaResearch Center of Biotechnology RAS, 33-1 Leninsky prospect, 119071, Moscow, Russia.
Anna EgorovaResearch Center of Biotechnology RAS, 33-1 Leninsky prospect, 119071, Moscow, Russia.
Penny ClarkeDepartment of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
J Smith LeserDepartment of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Joshua FrostDepartment of Immunology and Microbiology, Infectious Disease, Medicine and Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Michael RudyDepartment of Veterans Affairs, Aurora, CO, USA.
Kenneth L TylerDepartment of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Veterans Affairs, Aurora, CO, USA.
Thomas KloseDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Alexandrina S VolobuevaSaint Petersburg Pasteur Institute, 14 Mira Street, 197101, Saint Petersburg, Russia.
Svetlana V BelyaevskayaSaint Petersburg Pasteur Institute, 14 Mira Street, 197101, Saint Petersburg, Russia.
Vladimir V ZarubaevSaint Petersburg Pasteur Institute, 14 Mira Street, 197101, Saint Petersburg, Russia.
Richard J KuhnDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Vadim MakarovResearch Center of Biotechnology RAS, 33-1 Leninsky prospect, 119071, Moscow, Russia.
Sean EkinsCollaborations Pharmaceuticals Inc., Raleigh, NC, USA. Electronic address: sean@collaborationspharma.com.
University of Colorado Anschutz Medical Campus · USPurdue University West Lafayette · USSaint Petersburg Pasteur Institute · RUCollaborations Pharmaceuticals (United States) · USUtah State University · USNorth Carolina State University · US

Funding

Centralized assay datasets for modelling support of small drug discovery organizationsR44GM122196 · NIGMS · COLLABORATIONS PHARMACEUTICALS, INC. · PI EKINS, SEAN · 2018 to 2022
$3.3M
STRUCTURE OF A SMALL SPHERICAL VIRUSR01AI011219 · NIAID · PURDUE UNIVERSITY WEST LAFAYETTE · PI KUHN, RICHARD J. · 1985 to 2020
$2.4M
Genomic and molecular determinants of EV-D68 neuroinvasive diseaseR01AI171275 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Kenneth L. Tyler · 2023 to 2026
$1.6M
New generation of non-nucleoside RT HIV inhibitors avoiding HIV-associated neurocognitive disordersR01NS102164 · NINDS · COLLABORATIONS PHARMACEUTICALS, INC. · PI EKINS, SEAN, NELSON, JULIE AE · 2017 to 2019
$587k
NIAID NIH HHS HHSN272201700060CNIAID NIH HHS R01 AI011219NIAID NIH HHS R01 AI171275NIGMS NIH HHS R44 GM122196NINDS NIH HHS R01 NS102164
6 · The paper itself

Abstract

Enteroviruses (EV) cause a number of life-threatening infectious diseases. EV-D68 is known to cause respiratory illness in children that can lead to acute flaccid myelitis. Coxsackievirus B5 (CVB5) is commonly associated with hand-foot-mouth disease. There is no antiviral treatment available for either. We have developed an isoxazole-3-carboxamide analog of pleconaril (11526092) which displayed potent inhibition of EV-D68 (IC

Indexed as

EnterovirusEnterovirus D, HumanEnterovirus InfectionsHand, Foot and Mouth DiseaseAnimalsAntiviral AgentsCentral Nervous System Viral DiseasesCryoelectron MicroscopyEnterovirus B, HumanIsoxazolesMiceMyelitisNeuromuscular DiseasesOxadiazolesOxazolesAntiviral AgentsIsoxazolesOxadiazolesOxazolespleconarilAntiviralCoxsackievirus B5Cryo-electron microscopyEnterovirusesEV-D68

Identifiers

PMID37327878
PMCPMC10527014
OpenAlexW4380793001

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.