Evidence map›Paper›PMID 37327322›Full record

ArticleScience immunology2023

Activation of regulatory dendritic cells by Mertk coincides with a temporal wave of apoptosis in neonatal lungs.

Aaron Silva-Sanchez, Selene Meza-Perez, Mingyong Liu, Sara L Stone, Leopoldo Flores-Romo, Eric Ubil, Frances E Lund, Alexander F Rosenberg, Troy D Randall

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
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  8. More Than a Cleanup Crew: The Expanding Biology of Efferocytosis.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
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  14. Article
  15. Dendritic cell maturation in cancer.Nature reviews. Cancer · 2025
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Aaron Silva-SanchezDepartment of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-1882-2534
Selene Meza-PerezDepartment of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-7881-6964
Mingyong LiuDepartment of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-7546-2424
Sara L StoneDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-1689-8148
Leopoldo Flores-RomoDepartment of Cell Biology, Center for Advanced Research, National Polytechnic Institute, Cinvestav-IPN, Mexico City, Mexico.
Eric UbilDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-5112-464X
Frances E LundDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0003-3083-1246
Alexander F RosenbergDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Troy D RandallDepartment of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0003-0643-0311
University of Alabama at Birmingham · USInstituto Politécnico Nacional · MX

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
Regulation of Pathogenic Plasma Cells in Human SLEP01AI125180 · NIAID · EMORY UNIVERSITY · PI Ignacio E. Sanz · 2016 to 2026
$28.2M
PTP1b Inhibition Restores the Innate Anti-tumor Response During ChemotherapyR01CA262241 · NCI · UNIVERSITY OF KENTUCKY · PI Eric S Ubil · 2022 to 2026
$1.6M
Pulmonary Immunity To Pathogens In NeonatesR01AI100127 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RANDALL, TROY D · 2012 to 2016
$1.5M
Enhanced Immunotherapy by Targeting the Pros1:Macrophage Mer AxisK22CA237742 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI UBIL, ERIC S · 2020 to 2022
$577k
Multi-parameter, analytic flow cytometerS10OD032296 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RANDALL, TROY D · 2022 to 2022
$464k
NCI NIH HHS K22 CA237742NCI NIH HHS P30 CA013148NCI NIH HHS R01 CA262241NIAID NIH HHS P01 AI125180NIAID NIH HHS P30 AI027767NIAID NIH HHS R01 AI100127NIH HHS S10 OD032296
6 · The paper itself

Abstract

Multiple mechanisms restrain inflammation in neonates, most likely to prevent tissue damage caused by overly robust immune responses against newly encountered pathogens. Here, we identify a population of pulmonary dendritic cells (DCs) that express intermediate levels of CD103 (CD103

Indexed as

CD8-Positive T-LymphocytesPneumoniaAnimalsApoptosisc-Mer Tyrosine KinaseDendritic CellsLungMicec-Mer Tyrosine KinaseMertk protein, mouse

Identifiers

PMID37327322
PMCPMC10351240
OpenAlexW4380928249

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.