Evidence map›Paper›PMID 37327000›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2023

Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome.

Tori Stone, Licy L Yanes Cardozo, Toni N Oluwatade, Cheryl A Leone, Melanie Burgos, Faith Okifo, Lubna Pal, Jane F Reckelhoff, Nina S Stachenfeld

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Tori StoneJohn B. Pierce Laboratory, New Haven, Connecticut, United States.ORCID 0000-0002-8831-8659
Licy L Yanes CardozoDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0002-7295-1871
Toni N OluwatadeJohn B. Pierce Laboratory, New Haven, Connecticut, United States.
Cheryl A LeoneJohn B. Pierce Laboratory, New Haven, Connecticut, United States.
Melanie BurgosJohn B. Pierce Laboratory, New Haven, Connecticut, United States.
Faith OkifoJohn B. Pierce Laboratory, New Haven, Connecticut, United States.
Lubna PalDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United States.
Jane F ReckelhoffDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, United States.
Nina S StachenfeldJohn B. Pierce Laboratory, New Haven, Connecticut, United States.ORCID 0000-0002-6597-5031
Yale University · USJohn B. Pierce Laboratory · USUniversity of Mississippi Medical Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Babbette LaMarca, Jane F Reckelhoff · 2017 to 2026
$26.4M
Mechanisms of hypertension in women with polycystic ovary syndromeR01HL135089 · NHLBI · JOHN B. PIERCE LABORATORY, INC. · PI RECKELHOFF, JANE F, STACHENFELD, NINA · 2018 to 2021
$3.5M
Short Term Research Training: Students in Health Professional SchoolsT35DK104689 · NIDDK · YALE UNIVERSITY · PI LLOYD G CANTLEY, Sarwat I Chaudhry · 2015 to 2026
$2.6M
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL135089NIDDK NIH HHS T35 DK104689NIGMS NIH HHS P20 GM121334
6 · The paper itself

Abstract

We tested the hypothesis that hyperandrogenemia in androgen excess polycystic ovary syndrome (AE-PCOS) is a primary driver in blood pressure (BP) dysregulation via altered sympathetic nervous system activity (SNSA), reduced integrated baroreflex gain and increased renin-angiotensin system (RAS) activation. We measured resting SNSA (microneurography), integrated baroreflex gain, and RAS with lower body negative pressure in obese insulin-resistant (IR) women with AE-PCOS [

Indexed as

AndrogensBlood PressureInsulin ResistancePolycystic Ovary SyndromeTestosteroneBody Mass IndexFemaleHumansInsulinObesityAndrogensInsulinTestosteroneangiotensin-converting enzymebaroreflex gainblood pressuremuscle sympathetic nerve activityrenal angiotensin system

Identifiers

PMID37327000
PMCPMC10393337
OpenAlexW4380869793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.