ArticleInternational urology and nephrology2024
Based on functional and histopathological correlations: is diffusion kurtosis imaging valuable for noninvasive assessment of renal damage in early-stage of chronic kidney disease?
Article in International urology and nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Capability of multiparametric MRI to detect diabetic nephropathy in high-risk patients with type 2 diabetes: a prospective preliminary study.BMC medical imaging · 2026Article
- Assessment of renal interstitial fibrosis in glomerulonephritis using compartmental and non-compartmental diffusion magnetic resonance imaging.La Radiologia medica · 2026Article
- Motion and Flow Robust Free-Breathing Diffusion Kurtosis Imaging of the Kidney.NMR in biomedicine · 2025Article
- Probing Renal Microstructure and Function with Advanced Diffusion MRI: Concepts, Applications, Challenges, and Future Directions.Journal of magnetic resonance imaging : JMRI · 2024Review
- Multi-parametric MRI-based machine learning model for prediction of pathological grade of renal injury in a rat kidney cold ischemia-reperfusion injury model.BMC medical imaging · 2024Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo evaluate the potential of 3 T magnetic resonance diffusion kurtosis imaging (DKI) in assessing the renal damage in early-stage of chronic kidney disease (CKD) patients with normal or slightly changed functional index, using histopathology as reference standard.
methods49 CKD patients and 18 healthy volunteers were recruited in this study. CKD patients were divided into two groups based on estimated glomerular filtration rate (eGFR): Study group I (eGFR ≥ 90 ml/min/1.73 m
resultsThe cortex MD and MK showed significant difference among three groups (P < 0.05): trend of cortex MD: Study group II < Study group I < control group; trend of cortex MK: control group < Study group I < Study group II. The cortex MD and MK and medulla FA were correlated with eGFR and Interstitial fibrosis/Tubular atrophy score (0.3 < r < 0.5). Cortex MD and MK yielded an AUC of 0.752 for differentiating healthy volunteers from CKD patients with eGFR ≥ 90 ml/min/1.73 m
conclusionDKI shows potential in non-invasive and multi-parameter quantitative assessment of renal damage in early-stage of CKD patients and provide additional information for changes in renal function and histopathology.
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