ArticleAnnals of surgical oncology2023
Preoperative Frailty Assessment Predicts Postoperative Mortality, Delirium and Pneumonia in Elderly Lung Cancer Patients: A Retrospective Cohort Study.
Article in Annals of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Guideline for the Comprehensive Perioperative Management of Older Patients With Lung Cancer (2025).Journal of evidence-based medicine · 2026Guideline
- Unraveling the impact of frailty on postoperative delirium in elderly surgical patients: a systematic review and meta-analysis.BMC anesthesiology · 2025Pooled it
- Efficacy and safety of ciprofol for general anesthesia induction in female patients with frailty: a prospective randomized controlled trial.BMC anesthesiology · 2024Trial
- Effects of non-intubated spontaneous breathing on cerebral oxygen saturation and postoperative cognition in elderly patients with lung cancer undergoing video-assisted thoracoscopic surgery.Medical gas research · 2026Article
- Prediction Models for Postoperative Delirium Among Cancer Patients: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- Development and Validation of a Frailty Risk Prediction Model for Preoperative Non-Small-Cell Lung Cancer Patients: A Cross-Sectional Study.Annals of surgical oncology · 2026Article
- Preoperative Frailty Assessment: An Important Component of Preoperative Planning for Lung Cancer Surgery.Annals of surgical oncology · 2026Article
- Frailty as a Surgical Vital Sign: A Narrative Review of Risk Stratification and Outcomes in General Surgery.Cureus · 2026Review
- Nationwide survey of Japanese Physicians on Kampo medicine use in frailty care.Scientific reports · 2026Article
- Prevalence and predictors of frailty among older patients with lung cancer: a systematic review and meta-analysis.Journal of thoracic disease · 2026Article
- Applying the COM-B Model to Understand Adherence to Tele-Exercise Prehabilitation Among Older Patients with Lung Cancer: A Qualitative Study.Patient preference and adherence · 2026Article
- Emergency colorectal cancer in old and very elderly patients: a narrative review.Frontiers in oncology · 2026Review
- Postoperative delirium in patients with cancer: a narrative review of major risk factors.Sao Paulo medical journal = Revista paulista de medicina · 2026Review
- Serum NLRP3 levels are associated with postoperative delirium of elderly patients with lung cancer: an observational analytical study.Frontiers in neurology · 2026Observational
- Differential association of the 5-factor modified frailty index with postoperative pulmonary complications: specific prediction of infection risk after pulmonary lobectomy.Frontiers in medicine · 2026Article
- The Prediction of Postoperative Delirium Using the Preoperative Assessments of Frailty and Cognitive Impairment in Aged Patients.Clinical interventions in aging · 2024Article
- Preoperative Physical Dysfunction Characteristics and Influence Factors Among Elderly Patients with Early Lung Cancer: A Latent Class Analysis.Journal of multidisciplinary healthcare · 2024Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to investigate the predictive value of the 5-factor modified frailty index (mFI-5) for postoperative mortality, delirium and pneumonia in patients over 65 years of age undergoing elective lung cancer surgery.
methodsData were collected from a single-center retrospective cohort study conducted in a general tertiary hospital from January 2017 to August 2019. In total, the study included 1372 elderly patients aged over 65 who underwent elective lung cancer surgery. They were divided into frail group (mFI-5, 2-5), prefrail group (mFI-5, 1) and robust group (mFI-5, 0) on the basis of mFI-5 classification. The primary outcome was postoperative 1-year all-cause mortality. Secondary outcomes were postoperative pneumonia and postoperative delirium.
resultsFrailty group had the highest incidence of postoperative delirium (frailty 31.2% versus prefrailty 1.6% versus robust 1.5%, p < 0.001), postoperative pneumonia (frailty 23.5% versus prefrailty 7.2% versus robust 7.7%, p < 0.001), and postoperative 1-year mortality (frailty 7.0% versus prefrailty 2.2% versus robust 1.9%. p < 0.001). Frail patients have significantly longer length of hospitalization than those in the robust group and prefrail patients (p < 0.001). Multivariate analysis showed a clear link between frailty and increased risk of postoperative delirium (aOR 2.775, 95% CI 1.776-5.417, p < 0.001), postoperative pneumonia (aOR 3.291, 95% CI 2.169-4.993, p < 0.001) and postoperative 1-year mortality (aOR 3.364, 95% CI, 1.516-7.464, p = 0.003).
conclusionsmFI-5 has potential clinical utility in predicting postoperative death, delirium and pneumonia incidence in elderly patients undergoing radical lung cancer surgery. Frailty screening of patients (mFI-5) may provide benefits in risk stratification, targeted intervention efforts, and assist physicians in clinical decision-making.
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