Evidence map›Paper›PMID 37326765›Full record

ArticleBreast cancer research and treatment2023

Impact of non-adherence to endocrine therapy on recurrence risk in older women with stage I breast cancer after breast-conserving surgery.

Danielle Rodin, Rinku Sutradhar, Katarzyna J Jerzak, Ezra Hahn, Lena Nguyen, Matthew Castelo, Omolara Fatiregun, Cindy Fong, Danilo Giffoni M M Mata, Sabina Trebinjac and 2 more

Abstract read
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In one paragraph

Article in Breast cancer research and treatment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Danielle RodinRadiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada.
Rinku SutradharInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Katarzyna J JerzakDepartment of Medical Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Ezra HahnRadiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada.
Lena NguyenInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Matthew CasteloDivision of General Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Omolara FatiregunInstitute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Cindy FongInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Danilo Giffoni M M MataDepartment of Medical Oncology, London Regional Cancer Program, London, ON, Canada.
Sabina TrebinjacDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Lawrence PaszatDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Eileen RakovitchDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada. eileen.rakovitch@sunnybrook.ca.ORCID http://orcid.org/0000-0001-9647-2851
University of Toronto · CASunnybrook Health Science Centre · CAInstitute for Clinical Evaluative Sciences · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe examined the impact of non-adherence to adjuvant endocrine therapy (ET) on the risk and site of recurrence among older women with early stage, hormone receptor positive (HR+) breast cancer (EBC).

methodsA population-based cohort of women age ≥ 65 years with T1N0 HR + EBC who were diagnosed between 2010 and 2016 and treated with breast-conserving surgery (BCS) + ET was identified. Treatment and outcomes were ascertained through linkage with administrative databases. ET non-adherence was examined as a time-dependent covariate in multivariable cause-specific Cox regression models to evaluate its effect on the risks of ipsilateral local recurrence (LR), contralateral breast cancer, and distant metastases.

resultsThe population cohort includes 2637 women; 73% (N = 1934) received radiation (RT) + ET and 27% (N = 703) received ET alone. At a median follow-up of 8.14 years, the first event was LR in 3.6% of women treated with ET alone and 1.4% for those treated with RT + ET (p < 0.001); the risk of distant metastases was < 1% in both groups. The proportion of time adherent to ET was 69.0% among those treated with RT + ET and 62.8% for those treated with ET alone. On multivariable analysis, increasing proportion of time non-adherent to ET was associated with increased risk of LR ((HR = 1.52 per 20% increase in time; 95%CI 1.25, 1.85; p < 0.001), contralateral BC (HR = 1.55; 95%CI 1.30, 1.84; p < 0.001), and distant metastases (HR = 1.44; 95%CI 1.08, 1.94; p = 0.01) but absolute risks were low.

conclusionNon-adherence to adjuvant ET was associated with an increased risk of recurrence, but absolute recurrence rates were low.

Indexed as

Breast NeoplasmsAgedCombined Modality TherapyFemaleHumansMastectomy, SegmentalNeoplasm Recurrence, LocalNeoplasm StagingRiskBreast cancerContralateral breast cancerDistant metastasesEndocrine therapyLocal recurrenceNon-adherenceOlder womenPopulation-based

Identifiers

PMID37326765
OpenAlexW4380870903

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.