Evidence map›Paper›PMID 37326646›Full record

ArticleIntensive care medicine2023

ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies.

Giacomo Grasselli, Carolyn S Calfee, Luigi Camporota, Daniele Poole, Marcelo B P Amato, Massimo Antonelli, Yaseen M Arabi, Francesca Baroncelli, Jeremy R Beitler, Giacomo Bellani and 55 more

7 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Intensive care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 529 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
529citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05948332 completednot on this map

Definition and Management of Right Ventricular Injury in Adult Patients Receiving Extracorporeal Membrane Oxygenation for Respiratory Support Using the Delphi Method: A PRORVnet - Expert Consensus Statements

TypeobservationalSponsorPrashant NasaRan2023 to 2024Enrolled52ConditionsExtracorporeal Circulation, Complications, Extracorporeal Membrane Oxygenation Complication, Right Heart FailureArmsDelphi Rounds to generate consensus opinions among Experts
NCT06203405 narecruitingnot on this map

The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial

TypeinterventionalSponsorSiriraj HospitalRan2023 to 2026Enrolled214ConditionsRespiratory Failure, Critical Illness, Respiratory Distress Syndrome, Adult, Lung InjuryArmsTitrating sedation targeting both optimal P0.1 and appropriate arousal level, Fentanyl, Midazolam, Propofol, Dexmedetomidine
NCT06344234 active not recruitingnot on this map

Noninvasive Assessment of Inspiratory Effort and Tidal Distension During Noninvasive Ventilation. The INSPIRE Study.

Typeobservational_patient_registrySponsorUniversity of BariRan2023 to 2026Enrolled60ConditionsRespiratory Disease, Artificial RespirationArmsEnd-inspiratory Maneuvers
NCT06854627 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Continuous Prolonged Prone Position Versus Intermittent Daily Prone Position on Mortality in ARDS Patients: A Multicenter Randomized Controlled Trial

TypeinterventionalSponsorPontificia Universidad Catolica de ChileRan2025 to 2028Enrolled780ConditionsAcute Respiratory Distress SyndromeArmsDaily prone position sessions, Prolonged prone position sessions
NCT07438015 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

VEXUS-REA : Evaluation of Ultrasound Parameters of Venous Congestion in Patients in a Medical Intensive Care Unit

TypeinterventionalSponsorCentre Hospitalier Universitaire de BesanconRan2026 to 2026Enrolled525ConditionsVenous CongestionArmsVenous ultrasound (inferior vena cava, portal vein, suprahepatic vein, and renal vein to calculate the VEXUS score, femoral vein and popliteal vein)
NCT07452952 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Relationship Between the Level of Positive End-expiratory Pressure and Venous Congestion During Acute Respiratory Distress Syndrome.

TypeobservationalSponsorUniversity Hospital, AngersRan2026 to 2027Enrolled30ConditionsMechanical Ventilation, Acute Respiratory Distress Syndrome (ARDS)ArmsNon-interventionnal study
NCT07511582 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy, Safety, and Tolerability of Methylprednisolone in Critically Ill Patients With the Hyperinflammatory Phenotype: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Trial

TypeinterventionalSponsorBin DuRan2026 to 2028Enrolled150ConditionsSepsis, Acute Respiratory Distress SyndromeArmsMethylprednisolone (MP), Placebo
3 · Its place in the literature

Who cites it

529 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  8. [S3 guideline on sepsis-prevention, diagnosis, therapy, and follow-up care-update 2025].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025
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469 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

65 authors.

Giacomo Grasselli *Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. giacomo.grasselli@unimi.it.ORCID 0000-0002-1735-1400
Carolyn S Calfee *Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Luigi Camporota *Department of Adult Critical Care, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Daniele PooleOperative Unit of Anesthesia and Intensive Care, S. Martino Hospital, Belluno, Italy.
Marcelo B P AmatoHospital das Clinicas, Universidade de São Paulo, São Paulo, Brazil.
Massimo AntonelliDepartment of Anesthesiology Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Yaseen M ArabiIntensive Care Department, Ministry of the National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia.
Francesca BaroncelliDepartment of Anesthesia and Intensive Care, San Giovanni Bosco Hospital, Torino, Italy.
Jeremy R BeitlerCenter for Acute Respiratory Failure and Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, New York, NY, USA.
Giacomo BellaniCentre for Medical Sciences - CISMed, University of Trento, Trento, Italy.
Geoff BellinganIntensive Care Medicine, University College London, NIHR University College London Hospitals Biomedical Research Centre, London, UK.
Bronagh BlackwoodWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.
Lieuwe D J BosIntensive Care, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands.
Laurent BrochardKeenan Research Center, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, Canada.
Daniel BrodieDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Karen E A BurnsInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Alain CombesSorbonne Université, INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, F-75013, Paris, France.
Sonia D'ArrigoDepartment of Anesthesiology Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Daniel De BackerDepartment of Intensive Care, CHIREC Hospitals, Université Libre de Bruxelles, Brussels, Belgium.
Alexandre DemouleSorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Sharon EinavShaare Zedek Medical Center and Hebrew University Faculty of Medicine, Jerusalem, Israel.
Eddy FanInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Niall D FergusonDepartment of Medicine, Division of Respirology and Critical Care, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Jean-Pierre FratCHU De Poitiers, Médecine Intensive Réanimation, Poitiers, France.
Luciano GattinoniDepartment of Anesthesiology, University Medical Center Göttingen, Göttingen, Germany.
Claude GuérinUniversity of Lyon, Lyon, France.
Margaret S HerridgeCritical Care and Respiratory Medicine, University Health Network, Toronto General Research Institute, Institute of Medical Sciences, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Carol HodgsonThe Australian and New Zealand Intensive Care Research Center, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Catherine L HoughDivision of Pulmonary, Allergy and Critical Care Medicine, Oregon Health and Science University, Portland, OR, USA.
Samir JaberAnesthesia and Critical Care Department (DAR-B), Saint Eloi Teaching Hospital, University of Montpellier, Research Unit: PhyMedExp, INSERM U-1046, CNRS, 34295, Montpellier, France.
Nicole P JuffermansLaboratory of Translational Intensive Care, Erasmus Medical Center, Rotterdam, The Netherlands.
Christian KaragiannidisDepartment of Pneumology and Critical Care Medicine, Cologne-Merheim Hospital, ARDS and ECMO Centre, Kliniken Der Stadt Köln gGmbH, Witten/Herdecke University Hospital, Cologne, Germany.
Jozef KeseciogluDepartment of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Arthur KwizeraMakerere University College of Health Sciences, School of Medicine, Department of Anesthesia and Intensive Care, Kampala, Uganda.
John G LaffeyAnesthesia and Intensive Care Medicine, School of Medicine, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.
Jordi ManceboIntensive Care Department, Hospital Universitari de La Santa Creu I Sant Pau, Barcelona, Spain.
Michael A MatthayDepartments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Daniel F McAuleyWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.
Alain MercatDépartement de Médecine Intensive Réanimation, CHU d'Angers, Université d'Angers, Angers, France.
Nuala J MeyerUniversity of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Marc MossDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado, School of Medicine, Aurora, CO, USA.
Laveena MunshiInterdepartmental Division of Critical Care Medicine, Sinai Health System, University of Toronto, Toronto, Canada.
Sheila N MyatraDepartment of Anesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India.
Michelle Ng GongDivision of Pulmonary and Critical Care Medicine, Montefiore Medical Center, Bronx, New York, NY, USA.
Laurent PapazianBastia General Hospital Intensive Care Unit, Bastia, France.
Bhakti K PatelSection of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, IL, USA.
Mariangela PellegriniAnesthesia and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Anders PernerDepartment of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Antonio PesentiDepartment of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Lise PiquilloudAdult Intensive Care Unit, University Hospital and University of Lausanne, Lausanne, Switzerland.
Haibo QiuJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, China.
Marco V RanieriAlma Mater Studiorum - Università di Bologna, Bologna, Italy.
Elisabeth RivielloDivision of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Arthur S SlutskyInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Renee D StapletonDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont Larner College of Medicine, Burlington, VT, USA.
Charlotte SummersDepartment of Medicine, University of Cambridge Medical School, Cambridge, UK.
Taylor B ThompsonDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Carmen S Valente BarbasUniversity of São Paulo Medical School, São Paulo, Brazil.
Jesús VillarLi Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada.
Lorraine B WareDepartments of Medicine and Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Björn WeissDepartment of Anesthesiology and Intensive Care Medicine (CCM CVK), Charitè - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.
Fernando G ZampieriAcademic Research Organization, Albert Einstein Hospital, São Paulo, Brazil.
Elie AzoulayMédecine Intensive et Réanimation, APHP, Hôpital Saint-Louis, Paris Cité University, Paris, France.
Maurizio CecconiDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
European Society of Intensive Care Medicine Taskforce on ARDS

Funding

Respiratory Drive in Acute Respiratory FailureR01HL168102 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jeremy R. Beitler · 2023 to 2026
$3.2M
Early Mobilization: Operationalizing Big Data & Implementation Science to Lead Expansion to ICUs (E-MOBILE-ICU)K23HL148387 · NHLBI · UNIVERSITY OF CHICAGO · PI PATEL, BHAKTI KIRAN · 2020 to 2024
$812k
NHLBI NIH HHS K23 HL148387NHLBI NIH HHS R01 HL168102
6 · The paper itself

Abstract

The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to adult patients and to non-pharmacological respiratory support strategies across different aspects of acute respiratory distress syndrome (ARDS), including ARDS due to coronavirus disease 2019 (COVID-19). These guidelines were formulated by an international panel of clinical experts, one methodologist and patients' representatives on behalf of the ESICM. The review was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement recommendations. We followed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to assess the certainty of evidence and grade recommendations and the quality of reporting of each study based on the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) network guidelines. The CPG addressed 21 questions and formulates 21 recommendations on the following domains: (1) definition; (2) phenotyping, and respiratory support strategies including (3) high-flow nasal cannula oxygen (HFNO); (4) non-invasive ventilation (NIV); (5) tidal volume setting; (6) positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM); (7) prone positioning; (8) neuromuscular blockade, and (9) extracorporeal life support (ECLS). In addition, the CPG includes expert opinion on clinical practice and identifies the areas of future research.

Indexed as

COVID-19Respiratory Distress SyndromeAdultCritical CareHumansPositive-Pressure RespirationRespiration, ArtificialAcute hypoxemic respiratory failureAcute respiratory distress syndromeExtracorporeal membrane oxygenationMechanical ventilationNon-invasive ventilationPractice guidelinesPrognosisProne position

Identifiers

PMID37326646
PMCPMC10354163

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.