Evidence map›Paper›PMID 37326526›Full record

ArticleThe Journal of clinical endocrinology and metabolism2023

Hormones and Aging: An Endocrine Society Scientific Statement.

Anne R Cappola, Richard J Auchus, Ghada El-Hajj Fuleihan, David J Handelsman, Rita R Kalyani, Michael McClung, Cynthia A Stuenkel, Michael O Thorner, Joseph G Verbalis

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
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  3. Copeptin kinetics in healthy aging.The Journal of clinical endocrinology and metabolism · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 3 countries.

Anne R CappolaDivision of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-0883-9754
Richard J AuchusDepartments of Pharmacology and Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6815-6181
Ghada El-Hajj FuleihanCalcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, Division of Endocrinology, Department of Internal Medicine, American University of Beirut, Beirut 1107-2020, Lebanon.ORCID 0000-0002-2076-5858
David J HandelsmanANZAC Research Institute, University of Sydney and Andrology Department, Concord Repatriation General Hospital, Sydney 2139, Australia.ORCID 0000-0002-4200-7476
Rita R KalyaniDivision of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-1530-6884
Michael McClungOregon Osteoporosis Center, Portland, OR 97213, USA.ORCID 0000-0002-7827-0778
Cynthia A StuenkelDepartment of Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.ORCID 0000-0003-0943-9450
Michael O ThornerDivision of Endocrinology and Metabolism, University of Virginia, Charlottesville, VA 22903, USA.ORCID 0000-0003-1167-8266
Joseph G VerbalisDivision of Endocrinology and Metabolism, Georgetown University Medical Center, Washington, DC 20057, USA.ORCID 0000-0003-3704-2119
American University of Beirut · LBBone Health and Osteoporosis Foundation · USBrigham and Women's Hospital · USGeorgetown University · USJohns Hopkins University · USThe University of Sydney · AUUniversity of California San Diego · USUniversity of Michigan · USUniversity of Pennsylvania · US

Funding

Midcareer Investigator Award in Patient-Oriented Research in AgingK24AG042765 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CAPPOLA, ANNE R · 2013 to 2024
$1.7M
NIA NIH HHS K24 AG042765
6 · The paper itself

Abstract

Multiple changes occur across various endocrine systems as an individual ages. The understanding of the factors that cause age-related changes and how they should be managed clinically is evolving. This statement reviews the current state of research in the growth hormone, adrenal, ovarian, testicular, and thyroid axes, as well as in osteoporosis, vitamin D deficiency, type 2 diabetes, and water metabolism, with a specific focus on older individuals. Each section describes the natural history and observational data in older individuals, available therapies, clinical trial data on efficacy and safety in older individuals, key points, and scientific gaps. The goal of this statement is to inform future research that refines prevention and treatment strategies in age-associated endocrine conditions, with the goal of improving the health of older individuals.

Indexed as

Diabetes Mellitus, Type 2OsteoporosisAgedAgingHormonesHumansThyroid GlandHormonesadrenalandrogendiabetesendocrinologyestrogengrowth hormoneosteoporosisthyroidvitamin Dwater metabolism

Identifiers

PMID37326526
PMCPMC11491666
OpenAlexW4380872056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.