Evidence map›Paper›PMID 37326508›Full record

ArticleRadiology. Imaging cancer2023

Using US Twinkling Artifact to Identify Breast Biopsy Markers: Brief Report.

Christine U Lee, Mara A Piltin, Dan Moldoveanu, Matthew W Urban, Gina K Hesley

Open access · diamondAbstract read
In one paragraph

Article in Radiology. Imaging cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Selection of Breast Biopsy Markers: Effect on Breast Imaging Procedures, Follow-up, and Costs.Radiographics : a review publication of the Radiological Society of North America, Inc · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Breast ultrasound knobology and the knobology of twinkling for marker detection.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2024
    Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christine U LeeFrom the Department of Radiology, Division of Breast Imaging and Intervention (C.U.L., G.K.H.), Department of Surgery, Division of Breast and Melanoma Surgical Oncology (M.A.P., D.M.), Department of Radiology, Division of Radiology Research (M.W.U.), and Department of Physiology and Biomedical Engineering (M.W.U.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.ORCID 0000-0001-5298-6949
Mara A PiltinFrom the Department of Radiology, Division of Breast Imaging and Intervention (C.U.L., G.K.H.), Department of Surgery, Division of Breast and Melanoma Surgical Oncology (M.A.P., D.M.), Department of Radiology, Division of Radiology Research (M.W.U.), and Department of Physiology and Biomedical Engineering (M.W.U.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Dan MoldoveanuFrom the Department of Radiology, Division of Breast Imaging and Intervention (C.U.L., G.K.H.), Department of Surgery, Division of Breast and Melanoma Surgical Oncology (M.A.P., D.M.), Department of Radiology, Division of Radiology Research (M.W.U.), and Department of Physiology and Biomedical Engineering (M.W.U.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Matthew W UrbanFrom the Department of Radiology, Division of Breast Imaging and Intervention (C.U.L., G.K.H.), Department of Surgery, Division of Breast and Melanoma Surgical Oncology (M.A.P., D.M.), Department of Radiology, Division of Radiology Research (M.W.U.), and Department of Physiology and Biomedical Engineering (M.W.U.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.ORCID 0000-0003-1360-4287
Gina K HesleyFrom the Department of Radiology, Division of Breast Imaging and Intervention (C.U.L., G.K.H.), Department of Surgery, Division of Breast and Melanoma Surgical Oncology (M.A.P., D.M.), Department of Radiology, Division of Radiology Research (M.W.U.), and Department of Physiology and Biomedical Engineering (M.W.U.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.ORCID 0000-0003-1246-696X
Mayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast biopsy markers play an essential role in the surgical management of patients with clinically node-positive breast cancer. Marking a pathology-proven lymph node ensures accurate imaging assessment of response to neoadjuvant systemic therapy and decreased false-negative rates in sentinel lymph node biopsy. There is a clinically unmet need to make breast biopsy markers, particularly in the axilla, more sonographically visible or identifiable for preoperative localization purposes. Previously described color Doppler US twinkling artifact of some breast biopsy markers in in vitro gel phantoms and in ex vivo cadaveric breasts suggests that twinkling of such markers can be leveraged for improved in vivo detection. In this retrospective case series of eight female patients (mean age, 58.6 years ± 12.3 [SD]), conventional B-mode US imaging failed to identify the biopsy marker associated with a surgical target in the breast or in an axillary lymph node. However, in each patient, the marker was successfully identified with the help of color Doppler US twinkling.

Indexed as

ArtifactsBreast NeoplasmsFemaleHumansLymph NodesMiddle AgedRetrospective StudiesSentinel Lymph Node BiopsyArtifactsBiopsy MarkerBreastColor Doppler USLymphaticUltrasound

Identifiers

PMID37326508
PMCPMC10413298
OpenAlexW4380871038

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.