Evidence map›Paper›PMID 37326431›Full record

ArticlemBio2023

A cathepsin C-like protease mediates the post-translation modification of

L Brock Thornton, Melanie Key, Chiara Micchelli, Andrew J Stasic, Samuel Kwain, Katherine Floyd, Silvia N J Moreno, Brian N Dominy, Daniel C Whitehead, Zhicheng Dou

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. TgRON3 Links the Moving Junction to Microneme Secretion and Parasite Motility in Toxoplasma gondii.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

L Brock ThorntonDepartment of Biological Sciences, Clemson University , Clemson, South Carolina, USA.
Melanie KeyDepartment of Biological Sciences, Clemson University , Clemson, South Carolina, USA.
Chiara MicchelliDepartment of Biological Sciences, Clemson University , Clemson, South Carolina, USA.
Andrew J StasicCenter for Tropical and Emerging Global Diseases, University of Georgia , Athens, Georgia, USA.
Samuel KwainDepartment of Chemistry, Clemson University , Clemson, South Carolina, USA.
Katherine FloydDepartment of Biological Sciences, Clemson University , Clemson, South Carolina, USA.
Silvia N J MorenoCenter for Tropical and Emerging Global Diseases, University of Georgia , Athens, Georgia, USA.ORCID 0000-0002-2041-6295
Brian N DominyDepartment of Chemistry, Clemson University , Clemson, South Carolina, USA.
Daniel C WhiteheadDepartment of Chemistry, Clemson University , Clemson, South Carolina, USA.
Zhicheng DouDepartment of Biological Sciences, Clemson University , Clemson, South Carolina, USA.ORCID 0000-0003-1887-1181
Clemson University · USUniversity of Georgia · US

Funding

Regulation of Cryptosporidium DevelopmentP20GM146584 · NIGMS · CLEMSON UNIVERSITY · PI JAMES Culvin MORRIS · 2022 to 2026
$13.5M
Training in Tropical and Emerging Global Diseases - SupplementT32AI060546 · NIAID · UNIVERSITY OF GEORGIA (UGA) · PI Silvia N Moreno, Vasant Muralidharan · 2004 to 2026
$5.1M
The Toxoplasma apicoplast and calcium signalingR01AI128356 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2017 to 2021
$2.0M
Regulation of the physiology and function of the digestive vacuole in Toxoplasma gondiiR01AI143707 · NIAID · CLEMSON UNIVERSITY · PI DOU, ZHICHENG · 2020 to 2024
$1.8M
The plant-like vacuole of Toxoplasma gondiiR01AI096836 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2012 to 2016
$1.8M
NIAID NIH HHS R01 AI096836NIAID NIH HHS R01 AI128356NIAID NIH HHS R01 AI143707NIAID NIH HHS T32 AI060546NIGMS NIH HHS P20 GM146584
6 · The paper itself

Abstract

Microbial pathogens use proteases for their infections, such as digestion of proteins for nutrients and activation of their virulence factors. As an obligate intracellular parasite,

Indexed as

Protein Processing, Post-TranslationalProtozoan ProteinsToxoplasmaCathepsin CHumansCathepsin CProtozoan Proteinsaminopeptidaseapicomplexancathepsin Cdigestive vacuoleegressinvasionlysosomeproteaseprotein traffickingToxoplasma gondii

Identifiers

PMID37326431
PMCPMC10470614
OpenAlexW4380870516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.