Evidence map›Paper›PMID 37326365›Full record

ArticleJournal of biomedical materials research. Part A2023

Injectable pulverized electrospun poly(lactic-co-glycolic acid) fibers improve human adipose tissue engraftment and volume retention.

Devleena Das, William R Lawrence, Ludmila Diaz-Starokozheva, Ana I Salazar-Puerta, Neil Ott, Erin R Goebel, Abhishek Damughatla, Pablo Vidal, Summer Gallentine, Jordan T Moore and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical materials research. Part A, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Devleena DasDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
William R LawrenceBiomedical Sciences Graduate Program, The Ohio State University College of Medicine, Columbus, Ohio, USA.ORCID 0000-0001-8639-3420
Ludmila Diaz-StarokozhevaDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Ana I Salazar-PuertaDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-4954-6226
Neil OttDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Erin R GoebelDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Abhishek DamughatlaDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Pablo VidalDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA.
Summer GallentineDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Jordan T MooreDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Douglas KayuhaNanofiber Solutions, Columbus, Ohio, USA.
Natalia C MendoncaDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Jared B AlbertDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Robert HouserCosmetic & Plastic Surgery of Columbus, Columbus, Ohio, USA.
Jed JohnsonNanofiber Solutions, Columbus, Ohio, USA.
Heather PowellDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Natalia Higuita-CastroDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-3297-6281
Kristin I StanfordDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA.
Daniel Gallego-PerezDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-6263-3191
The Ohio State University · USNanofiber Solutions (United States) · USColumbus Center · USShriners Hospitals for Children - Cincinnati · US

Funding

Novel nanoscale approaches to whole tissue reprogrammingDP2EB028110 · NIBIB · OHIO STATE UNIVERSITY · PI GALLEGO-PEREZ, DANIEL · 2018 to 2022
$2.7M
Non-Viral Modulation of Cutaneous Tissue Plasticity as a Therapy for DiabetesDP1DK126199 · NIDDK · OHIO STATE UNIVERSITY · PI GALLEGO-PEREZ, DANIEL · 2020 to 2020
$737k
NIBIB NIH HHS DP2 EB028110NIDDK NIH HHS DP1 DK126199NIH HHS
6 · The paper itself

Abstract

Autologous adipose tissue is commonly used for tissue engraftment for the purposes of soft tissue reconstruction due to its relative abundance in the human body and ease of acquisition using liposuction methods. This has led to the adoption of autologous adipose engraftment procedures that allow for the injection of adipose tissues to be used as a "filler" for correcting cosmetic defects and deformities in soft tissues. However, the clinical use of such methods has several limitations, including high resorption rates and poor cell survivability, which lead to low graft volume retention and inconsistent outcomes. Here, we describe a novel application of milled electrospun poly(lactic-co-glycolic acid) (PLGA) fibers, which can be co-injected with adipose tissue to improve engraftment outcomes. These PLGA fibers had no significant negative impact on the viability of adipocytes in vitro and did not elicit long-term proinflammatory responses in vivo. Furthermore, co-delivery of human adipose tissue with pulverized electrospun PLGA fibers led to significant improvements in reperfusion, vascularity, and retention of graft volume compared to injections of adipose tissue alone. Taken together, the use of milled electrospun fibers to enhance autologous adipose engraftment techniques represents a novel approach for improving upon the shortcomings of such methods.

Indexed as

Polyglycolic AcidTissue ScaffoldsAdipose TissueGlycolsHumansLactic AcidPolylactic Acid-Polyglycolic Acid CopolymerTissue EngineeringGlycolsLactic AcidPolyglycolic AcidPolylactic Acid-Polyglycolic Acid Copolymeradipocytesadipose tissue engraftmentelectrospinningpulverized PLGA fibers

Identifiers

PMID37326365
PMCPMC10527741
OpenAlexW4380872418

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.