ArticleMolecular biology and evolution2023
Uncovering the Genomic Basis of Infection Through Co-genomic Sequencing of Hosts and Parasites.
Article in Molecular biology and evolution, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Genomic insights into antagonistic coevolution: collagen-like protein expansion and genome plasticity in the Daphnia parasite Pasteuria ramosa.G3 (Bethesda, Md.) · 2026Article
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- Disentangling the role of parasite infectivity and density from host susceptibility in infection development and parasite proliferation.Biology letters · 2025Article
- Aphid herbivory on macrophytes drives adaptive evolution in an aquatic community via indirect effects.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genetic basis of resistance in hosts facing alternative infection strategies by a virulent bacterial pathogen.G3 (Bethesda, Md.) · 2025Article
- Inference of Host-Pathogen Interaction Matrices from Genome-Wide Polymorphism Data.Molecular biology and evolution · 2024Article
- Toward Ecologically Relevant Genetics of Interactions Between Host Plants and Plant Growth-Promoting Bacteria.Advanced genetics (Hoboken, N.J.) · 2024Article
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Authors and funding
3 authors.
Funding
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Abstract
Understanding the genomic basis of infectious disease is a fundamental objective in co-evolutionary theory with relevance to healthcare, agriculture, and epidemiology. Models of host-parasite co-evolution often assume that infection requires specific combinations of host and parasite genotypes. Co-evolving host and parasite loci are, therefore, expected to show associations that reflect an underlying infection/resistance allele matrix, yet little evidence for such genome-to-genome interactions has been observed among natural populations. We conducted a study to search for this genomic signature across 258 linked host (Daphnia magna) and parasite (Pasteuria ramosa) genomes. Our results show a clear signal of genomic association between multiple epistatically interacting loci in the host genome, and a family of genes encoding for collagen-like protein in the parasite genome. These findings are supported by laboratory-based infection trials, which show strong correspondence between phenotype and genotype at the identified loci. Our study provides clear genomic evidence of antagonistic co-evolution among wild populations.
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