ReviewDevelopmental neurobiology
Development of the hippocampal CA2 region and the emergence of social recognition.
Review in Developmental neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 14 citations in OpenAlex.
- Developmental Scarcity Induces Sex Differences in Social Recognition and CA2 Perineuronal Nets.eNeuro · 2026Article
- SegJointGene: joint cell segmentation and spatial gene prioritization by information entropy guided convolutional neural networks.Bioinformatics (Oxford, England) · 2026Article
- New neurons flatten social hierarchies.Scientific reports · 2026Article
- The tyrosine phosphatase STEP is a developmental suppressor of synaptogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Developmental CA2 perineuronal net reduction restores social memory in Shank3 mutant mice.Communications biology · 2026Article
- Different early-life adversity paradigms have disparate effects on maternal care, neuronal activation, and social behavior in developing mice.Neurobiology of stress · 2026Article
- Histomorphometric Evaluation of Subchronic and Chronic Effects of Novel Experimental Calcium Aluminate- and Calcium Silicate-Based Dental Cement Materials on Rat Liver, Kidney, Brain, and Spleen Tissues.Journal of functional biomaterials · 2026Article
- Representations of social experience in hippocampal circuits.Trends in cognitive sciences · 2026Review
- Developmental scarcity induces sex differences in social recognition and CA2 perineuronal nets.bioRxiv : the preprint server for biology · 2026Article
- From Synaptic Plasticity and Critical Periods to Social Behavior and Stress: Getting to, and Staying in, CA2.Hippocampus · 2026Review
- Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Developmental CA2 perineuronal net reduction restores social memory inbioRxiv : the preprint server for biology · 2025Article
- Protective effects of polydatin amphiphilic chitosan nanocarriers against an aluminum chloride-induced model of Alzheimer's disease in rats: relevance to its anti-inflammatory and antioxidant effects.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Deciphering the Functions of Raphe-Hippocampal Serotonergic and Glutamatergic Circuits and Their Deficits in Alzheimer's Disease.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Social memories formed in early life, like those for family and unrelated peers, are known to contribute to healthy social interactions throughout life, although how the developing brain supports social memory remains relatively unexplored. The CA2 subregion of the hippocampus is involved in social memory function, but most literature on this subject is restricted to studies of adult rodents. Here, we review the current literature on the embryonic and postnatal development of hippocampal subregion CA2 in mammals, with a focus on the emergence of its unusual molecular and cellular characteristics, including its notably high expression of plasticity-suppressing molecules. We also consider the connectivity of the CA2 with other brain areas, including intrahippocampal regions, such as the dentate gyrus, CA3, and CA1 regions, and extrahippocampal regions, such as the hypothalamus, ventral tegmental area, basal forebrain, raphe nuclei, and the entorhinal cortex. We review developmental milestones of CA2 molecular, cellular, and circuit-level features that may contribute to emerging social recognition abilities for kin and unrelated conspecifics in early life. Lastly, we consider genetic mouse models related to neurodevelopmental disorders in humans in order to survey evidence about whether atypical formation of the CA2 may contribute to social memory dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.