ArticleOncology reports2023
Downregulation of fascin induces collective cell migration in triple‑negative breast cancer.
Article in Oncology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Fascin-1 expression is associated with EMT and recurrence in thymic carcinoma: a clinicopathologic study.Medical molecular morphology · 2026Article
- Clusterin Promotes the Migration and Invasion of Highly Aggressive Breast Cancer Cells Through Molecular Mechanisms That Affect the Cell Cytoskeleton and Extracellular Matrix Dynamics.International journal of molecular sciences · 2026Article
- Hypoxia‑mediated Krebs von den Lungen‑6 expression in breast cancer: Implications for tumor invasion and metastasis.Oncology reports · 2026Article
- Breast carcinoma arising in a fibroadenoma: A case series of 16 patients and review of the literature.Oncology letters · 2024Article
- Encapsulated papillary carcinoma of the breast: A single institution experience.Oncology letters · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer (BC) is one of the most common types of cancer affecting female patients. Triple‑negative BC (TNBC) is an aggressive subtype. Fascin, an actin‑bundling protein, serves a significant role in cancer metastasis. Fascin overexpression is associated with poor prognosis of BC. To confirm the relationship between fascin expression and BC malignancy, the present study reviewed clinical data from 100 Japanese patients with BC and performed fresh immunohistochemical fascin examination of tissue samples. Statistical analyses showed metastasis or recurrence in 11 of 100 patients and a significant association between high fascin expression and poor prognosis. The TNBC subtype was also associated with high fascin expression. However, a few cases developed poor prognosis regardless of negative or slightly positive fascin expression. The present study established fascin knockdown (FKD) MDA‑MB‑231, a TNBC cell line, and investigated morphological effects of fascin on TNBC cells. FKD cells exhibited cell‑cell connections and bulbous nodules of various sizes on the cell surface. Conversely, non‑FKD MDA‑MB‑231 cells exhibited loose cell‑cell connections with numerous filopodia on the cell surface. Filopodia, actin‑rich plasma membrane protrusions, are composed of fascin and control cell‑cell interaction, migration and wound healing. Cancer metastasis is conventionally classified into two mechanisms: single and collective cell migration. Fascin increases cancer metastasis by single cell migration via filopodia on the cell surface. However, the present study suggested that following FKD, TNBC cells lost filopodia and exhibited collective cell migration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.