Evidence map›Paper›PMID 37325994›Full record

ArticlePsychological medicine2023

Early life adversity predicts an accelerated cellular aging phenotype through early timing of puberty.

Elissa J Hamlat, Torsten B Neilands, Barbara Laraia, Joshua Zhang, Ake T Lu, Jue Lin, Steve Horvath, Elissa S Epel

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  7. The epigenetic impacts of pubertal acceleration following early caregiver disruptions.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. The Impact of Early Life Adversity on Peripubertal Accelerated Epigenetic Aging and Psychopathology.Journal of the American Academy of Child and Adolescent Psychiatry · 2025
    Article
  9. Article
  10. Maternal childhood adversity accelerates epigenetic aging of children.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Elissa J HamlatDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.ORCID 0000-0001-7339-8222
Torsten B NeilandsDivision of Prevention Science | Department of Medicine, University of California, San Francisco, CA, USA.
Barbara LaraiaSchool of Public Health, University of California, Berkeley, CA, USA.
Joshua ZhangDepartment of Human Genetics, University of California, Los Angeles, CA, USA.
Ake T LuDepartment of Human Genetics, University of California, Los Angeles, CA, USA.
Jue LinDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.
Steve HorvathDepartment of Human Genetics, University of California, Los Angeles, CA, USA.
Elissa S EpelDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
University of California, San Francisco · USUniversity of California, Los Angeles · USUniversity of California, Berkeley · US

Funding

RESOURCE CENTER FOR AGING RESEARCH IN DIVERSE POPULATIONP30AG015272 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nynikka Palmer · 1997 to 2026
$19.5M
Psychology & Medicine: Translational Research on Stress, Behavior and DiseaseT32MH019391 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ADLER, NANCY E, EPEL, ELISSA S. · 1991 to 2022
$4.4M
Race, Stress and Dysregulated Eating: Maternal to Child Transmission of ObesityR01HD073568 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI EPEL, ELISSA S., LARAIA, BARBARA A · 2014 to 2018
$2.6M
Early Life Adversity, Cumulative Life Stress, Race, and Cellular Aging in Midlife Women and OffspringR01AG059677 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EPEL, ELISSA S., LARAIA, BARBARA A · 2019 to 2021
$1.7M
NIA NIH HHS P30 AG015272NIA NIH HHS P30AG015272NIA NIH HHS R01 AG059677NICHD NIH HHS R01 HD073568NIMH NIH HHS T32 MH019391
6 · The paper itself

Abstract

backgroundThe current study examined if early adversity was associated with accelerated biological aging, and if effects were mediated by the timing of puberty.

methodsIn early mid-life, 187 Black and 198 White (

resultsThere was an indirect effect of early adversity on accelerated aging through age at menarche (

conclusionsEarly abuse and being Black in the USA may both induce a phenotype of accelerated aging. Early adversity may begin to accelerate aging during childhood, in the form of early pubertal timing.

Indexed as

Adverse Childhood ExperiencesAdolescentAdultCellular SenescenceChildC-Reactive ProteinFemaleHumansInfantMenarchePubertyC-Reactive Proteinagingchild abuseepigenetic clockinflammationpubertytelomeres

Identifiers

PMID37325994
PMCPMC11131158
OpenAlexW4380872657

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.