Evidence map›Paper›PMID 37325935›Full record

ArticleCirculation research2023

Activation of the Aryl Hydrocarbon Receptor in Muscle Exacerbates Ischemic Pathology in Chronic Kidney Disease.

Nicholas Balestrieri, Victoria Palzkill, Caroline Pass, Jianna Tan, Zachary R Salyers, Chatick Moparthy, Ania Murillo, Kyoungrae Kim, Trace Thome, Qingping Yang and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 30 citations in OpenAlex.

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  20. Targeting Lactobacillus johnsonii to reverse chronic kidney disease.Signal transduction and targeted therapy · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Nicholas BalestrieriDepartment of Applied Physiology and Kinesiology (N.B., V.P., C.P., J.T., Z.R.S., C.M., A.M., K.K., T.T., Q.Y., L.F.F., T.E.R.), University of Florida, Gainesville.ORCID 0000-0001-9863-4420
Victoria PalzkillDepartment of Applied Physiology and Kinesiology (N.B., V.P., C.P., J.T., Z.R.S., C.M., A.M., K.K., T.T., Q.Y., L.F.F., T.E.R.), University of Florida, Gainesville.
Caroline PassDepartment of Applied Physiology and Kinesiology (N.B., V.P., C.P., J.T., Z.R.S., C.M., A.M., K.K., T.T., Q.Y., L.F.F., T.E.R.), University of Florida, Gainesville.
Jianna TanDepartment of Applied Physiology and Kinesiology (N.B., V.P., C.P., J.T., Z.R.S., C.M., A.M., K.K., T.T., Q.Y., L.F.F., T.E.R.), University of Florida, Gainesville.
Zachary R SalyersDepartment of Applied Physiology and Kinesiology (N.B., V.P., C.P., J.T., Z.R.S., C.M., A.M., K.K., T.T., Q.Y., L.F.F., T.E.R.), University of Florida, Gainesville.
Chatick MoparthyDepartment of Applied Physiology and Kinesiology (N.B., V.P., C.P., J.T., Z.R.S., C.M., A.M., K.K., T.T., Q.Y., L.F.F., T.E.R.), University of Florida, Gainesville.
Ania MurilloDepartment of Applied Physiology and Kinesiology (N.B., V.P., C.P., J.T., Z.R.S., C.M., A.M., K.K., T.T., Q.Y., L.F.F., T.E.R.), University of Florida, Gainesville.
Kyoungrae KimDepartment of Applied Physiology and Kinesiology (N.B., V.P., C.P., J.T., Z.R.S., C.M., A.M., K.K., T.T., Q.Y., L.F.F., T.E.R.), University of Florida, Gainesville.ORCID 0000-0001-9513-6469
Trace ThomeDepartment of Applied Physiology and Kinesiology (N.B., V.P., C.P., J.T., Z.R.S., C.M., A.M., K.K., T.T., Q.Y., L.F.F., T.E.R.), University of Florida, Gainesville.
Qingping YangDepartment of Applied Physiology and Kinesiology (N.B., V.P., C.P., J.T., Z.R.S., C.M., A.M., K.K., T.T., Q.Y., L.F.F., T.E.R.), University of Florida, Gainesville.
Kerri A O'MalleyDepartment of Surgery (K.A.O., S.A.B., S.T.S.), University of Florida, Gainesville.
Scott A BerceliDepartment of Surgery (K.A.O., S.A.B., S.T.S.), University of Florida, Gainesville.
Feng YueDepartment of Animal Sciences (F.Y.), University of Florida, Gainesville.
Salvatore T ScaliDepartment of Surgery (K.A.O., S.A.B., S.T.S.), University of Florida, Gainesville.ORCID 0000-0002-8128-3203
Leonardo F FerreiraDepartment of Applied Physiology and Kinesiology (N.B., V.P., C.P., J.T., Z.R.S., C.M., A.M., K.K., T.T., Q.Y., L.F.F., T.E.R.), University of Florida, Gainesville.ORCID 0000-0001-6581-5882
Terence E RyanDepartment of Applied Physiology and Kinesiology (N.B., V.P., C.P., J.T., Z.R.S., C.M., A.M., K.K., T.T., Q.Y., L.F.F., T.E.R.), University of Florida, Gainesville.ORCID 0000-0003-0780-029X
University of Florida · US

Funding

Redox basis of diaphragm mitochondrial dysfunction and atrophy in heart failureR01HL130318 · NHLBI · UNIVERSITY OF FLORIDA · PI FERREIRA, LEONARDO · 2016 to 2025
$3.9M
Molecular mechanisms regulating peripheral arterial disease pathobiology in chronic kidney diseaseR01HL149704 · NHLBI · UNIVERSITY OF FLORIDA · PI Terence E Ryan · 2020 to 2026
$3.6M
Impaired Mitochondrial Energetics is a Driver of Hemodialysis Access Related Hand DysfunctionR01HL148597 · NHLBI · UNIVERSITY OF FLORIDA · PI SCALI, SALVATORE T. · 2019 to 2023
$2.7M
Translational and Computational Analysis of Dialysis Fistula Maturation Failure-2R01DK119274 · NIDDK · UNIVERSITY OF FLORIDA · PI BERCELI, SCOTT A · 2019 to 2022
$2.2M
Chronic aryl hydrocarbon receptor activation and skeletal myopathy in chronic kidney diseaseF31DK128920 · NIDDK · UNIVERSITY OF FLORIDA · PI THOME, TRACE · 2021 to 2023
$122k
NHLBI NIH HHS R01 HL130318NHLBI NIH HHS R01 HL148597NHLBI NIH HHS R01 HL149704NIDDK NIH HHS F31 DK128920NIDDK NIH HHS R01 DK119274
6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD) accelerates the development of atherosclerosis, decreases muscle function, and increases the risk of amputation or death in patients with peripheral artery disease (PAD). However, the mechanisms underlying this pathobiology are ill-defined. Recent work has indicated that tryptophan-derived uremic solutes, which are ligands for AHR (aryl hydrocarbon receptor), are associated with limb amputation in PAD. Herein, we examined the role of AHR activation in the myopathy of PAD and CKD.

methodsAHR-related gene expression was evaluated in skeletal muscle obtained from mice and human PAD patients with and without CKD. AHR

resultsPAD patients and mice with CKD displayed significantly higher mRNA expression of classical AHR-dependent genes (

conclusionsThese findings establish AHR activation in muscle as a pivotal regulator of the ischemic limb pathology in CKD. Further, the totality of the results provides support for testing of clinical interventions that diminish AHR signaling in these conditions.

Indexed as

Muscular DiseasesPeripheral Arterial DiseaseRenal Insufficiency, ChronicAnimalsBasic Helix-Loop-Helix ProteinsHumansIschemiaMiceMice, KnockoutMuscle, SkeletalReceptors, Aryl HydrocarbonAhr protein, mouseBasic Helix-Loop-Helix ProteinsReceptors, Aryl Hydrocarbonhumanskidneymitochondriaperipheral artery diseaseuremia

Identifiers

PMID37325935
PMCPMC10330629
OpenAlexW4380872271

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.