Evidence map›Paper›PMID 37325651›Full record

SynthesisFrontiers in immunology2023

Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis.

Haiyang Kou, Lei Huang, Meng Jin, Qi He, Rui Zhang, Jianbing Ma

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 7 pooled it
20.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 7 syntheses or guidelines pooled it, 82 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Haiyang KouDepartment of Joint Surgery, Translational Medicine Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Lei HuangDepartment of Joint Surgery, Translational Medicine Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Meng JinDepartment of Joint Surgery, Translational Medicine Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Qi HeDepartment of Joint Surgery, Translational Medicine Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Rui ZhangDepartment of Joint Surgery, Translational Medicine Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jianbing MaDepartment of Joint Surgery, Translational Medicine Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xi'an Jiaotong University · CNXi'an Honghui Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The aim of this study is to evaluate the effectiveness and safety of curcumin in rheumatoid arthritis patients. Methods: A computerized search from PubMed, Embase, Cochrane Library, and Web of Science databases was performed until 3 March 2023. Literature screening, basic data extraction and risk of bias evaluation were independently performed by two researchers each. The quality evaluation of the literature was performed according to the Cochrane Handbook for Risk of Bias Assessment tool for treatment evaluation. Results: The current study includes six publications covering 539 rheumatoid arthritis patients. The activity of rheumatoid arthritis was assessed using erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), protein, disease activity score (DAS), rheumatoid factor (RF), Visual Analogue Scale (VAS) pain, tender joint count (TJC) and swollen joint count (SJC). ESR (MD = -29.47, 95% CI [-54.05, -4.88], Z=2.35, P = 0.02), DAS28 (MD = -1.20, 95% CI [-1.85, -0.55], Z=3.62, P = 0.0003), SJC (MD = -5.33, 95% CI [-9.90, -0.76], Z = 2.29, P = 0.02) and TJC (MD = -6.33, 95% CI [-10.86, -1.81], Z = 2.74, P = 0.006) showed significantly change in experimental patients compared with controls. Conclusion: Curcumin is beneficial for rheumatoid arthritis treatment. Inflammation levels and clinical symptoms in patients with rheumatoid arthritis can be improved by curcumin supplementation. Large sample randomized controlled trials on the effects of curcumin on patients with rheumatoid arthritis are needed in the future. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier (CRD42022361992).

Indexed as

Arthritis, RheumatoidCurcuminC-Reactive ProteinHumansInflammationRheumatoid FactorC-Reactive ProteinCurcuminRheumatoid Factorantioxidantsarthritiscurcumininflammatoryrheumatoid arthritis

Identifiers

PMID37325651
PMCPMC10264675
OpenAlexW4378903849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.