Evidence map›Paper›PMID 37325521›Full record

ArticleNanoscale advances2023

Co-delivery of a tumor microenvironment-responsive disulfiram prodrug and CuO

Fen-Ting Cheng, Ya-Di Geng, Yun-Xiao Liu, Xuan Nie, Xin-Ge Zhang, Zhao-Lin Chen, Li-Qin Tang, Long-Hai Wang, Ye-Zi You, Lei Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Stimuli-responsive bioengineered platforms for precision cancer therapy.Frontiers in bioengineering and biotechnology · 2026
    Review
  4. Review
  5. Recent advances in copper homeostasis-involved tumor theranostics.Asian journal of pharmaceutical sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Fen-Ting ChengDepartment of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei Anhui 230001 China zhanglei6@ustc.edu.cn tangliqin@ustc.edu.cn.ORCID https://orcid.org/0000-0001-9542-0435
Ya-Di GengDepartment of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei Anhui 230001 China zhanglei6@ustc.edu.cn tangliqin@ustc.edu.cn.
Yun-Xiao LiuInstitute of Clinical Pharmacology, Anhui Medical University Hefei Anhui 230032 China.
Xuan NieDepartment of Polymer Science and Engineering, University of Science and Technology of China Hefei Anhui 230026 China hiwang@ustc.edu.cn.ORCID https://orcid.org/0000-0002-7757-9538
Xin-Ge ZhangInstitute of Clinical Pharmacology, Anhui Medical University Hefei Anhui 230032 China.
Zhao-Lin ChenDepartment of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei Anhui 230001 China zhanglei6@ustc.edu.cn tangliqin@ustc.edu.cn.
Li-Qin TangDepartment of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei Anhui 230001 China zhanglei6@ustc.edu.cn tangliqin@ustc.edu.cn.
Long-Hai WangDepartment of Polymer Science and Engineering, University of Science and Technology of China Hefei Anhui 230026 China hiwang@ustc.edu.cn.
Ye-Zi YouDepartment of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei Anhui 230001 China zhanglei6@ustc.edu.cn tangliqin@ustc.edu.cn.ORCID https://orcid.org/0000-0003-0319-4165
Lei ZhangDepartment of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei Anhui 230001 China zhanglei6@ustc.edu.cn tangliqin@ustc.edu.cn.
University of Science and Technology of China · CNAnhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disulfiram (DSF) has been used as a hangover drug for more than seven decades and was found to have potential in cancer treatment, especially mediated by copper. However, the uncoordinated delivery of disulfiram with copper and the instability of disulfiram limit its further applications. Herein, we synthesize a DSF prodrug using a simple strategy that could be activated in a specific tumor microenvironment. Poly amino acids are used as a platform to bind the DSF prodrug through the B-N interaction and encapsulate CuO

Identifiers

PMID37325521
PMCPMC10262962
OpenAlexW4380872683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.