ArticleExploration (Beijing, China)2022
A dynamic covalent polymeric antimicrobial for conquering drug-resistant bacterial infection.
Article in Exploration (Beijing, China), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 105 citations in OpenAlex.
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- High electron transfer efficiency accordion-shaped HNiZn heterostructure nanozyme for low-temperature photo-catalytic enhanced therapy of bacterial infection wounds.Materials today. Bio · 2025Article
- Ruthenium-quercetin coordinated nanotherapeutics with macrophage polarization regulation to rapidly promote bacterial-infected wound healing.Materials today. Bio · 2025Article
- Applications of Lignin-Dervied Carbon Quantum Dots: Current Status and Challenges.Exploration (Beijing, China) · 2025Review
- Antibacterial Polymers Based on Two Orthogonal Binding Motifs Coalesce with Bacterial Matter.ACS applied bio materials · 2025Article
- Evaluation of Antimicrobial Performance of Calcium Dihydroxide (Ca(OH)Antibiotics (Basel, Switzerland) · 2025Article
- Emodin Enhanced Microwave-Responsive Heterojunction with Powerful Bactericidal Capacity and Immunoregulation for Curing Bacteria-Infected Osteomyelitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Review
- Injectable polypeptide-polysaccharide depot for preventing postoperative tumor recurrence by concurrentMaterials today. Bio · 2024Article
- Clinical Trial Findings and Drug Development Challenges for Curcumin in Infectious Disease Prevention and Treatment.Life (Basel, Switzerland) · 2024Review
- Emerging Trends in Dissolving-Microneedle Technology for Antimicrobial Skin-Infection Therapies.Pharmaceutics · 2024Review
- Photoresponsive Multirole Nanoweapon Camouflaged by Hybrid Cell Membrane Vesicles for Efficient Antibacterial Therapy of Pseudomonas aeruginosa-Infected Pneumonia and Wound.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The Influence of Zinc Oxide and Zinc Stearate on the Antimicrobial Activity of Coatings Containing Raspberry and Chokeberry Extracts.Molecules (Basel, Switzerland) · 2024Article
- Various Antibacterial Strategies Utilizing Titanium Dioxide Nanotubes Prepared via Electrochemical Anodization Biofabrication Method.Biomimetics (Basel, Switzerland) · 2024Review
- Hyaluron-Based Bionanocomposites of Silver Nanoparticles with Graphene Oxide as Effective Growth Inhibitors of Wound-Derived Bacteria.International journal of molecular sciences · 2024Article
- Colistin: Lights and Shadows of an Older Antibiotic.Molecules (Basel, Switzerland) · 2024Review
- Pituitary abscess: a descriptive analysis of a series of 19 patients-a multi-center experience.European journal of medical research · 2024Article
- Recent design strategies for boosting chemodynamic therapy of bacterial infections.Exploration (Beijing, China) · 2024Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing bacterial drug resistance to antibiotics has posed a major threat to contemporary public health, which resulted in a large number of people suffering from serious infections and ending up dying without any effective therapies every year. Here, a dynamic covalent polymeric antimicrobial, based on phenylboronic acid (PBA)-installed micellar nanocarriers incorporating clinical vancomycin and curcumin, is developed to overcome drug-resistant bacterial infections. The formation of this antimicrobial is facilitated by reversible dynamic covalent interactions between PBA moieties in polymeric micelles and diols in vancomycin, which impart favorable stability in blood circulation and excellent acid-responsiveness in the infection microenvironment. Moreover, the structurally similar aromatic vancomycin and curcumin molecules can afford π-π stacking interaction to realize simultaneous delivery and release of payloads. In comparison with monotherapy, this dynamic covalent polymeric antimicrobial demonstrated more significant eradication of drug-resistant bacteria in vitro and in vivo due to the synergism of the two drugs. Furthermore, the achieved combination therapy shows satisfied biocompatibility without unwanted toxicity. Considering various antibiotics contain diol and aromatic structures, this simple and robust strategy can become a universal platform to combat the ever-threatening drug-resistant infectious diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.